Publications by authors named "Anna Hotovely-Salomon"
Haptide-coated collagen sponge as a bioactive matrix for tissue regeneration.
J Biomed Mater Res B Appl Biomater
February 2008
Article Synopsis
- A new type of biomaterial called Haptide-coated Collagen was developed, using a specific peptide from fibrinogen that enhances cell adhesion.
- The optimal concentration of Haptide for enhancing cell attachment was found to be 5-10 mg Haptide/g collagen, leading to a more stable material that degrades slower than untreated collagen.
- In animal studies, Haptized collagen attracted more fibroblasts and demonstrated improved integration with tissue, suggesting promising uses in medical fields like tissue regeneration and wound healing.
Heat denaturation of fibrinogen to develop a biomedical matrix.
J Biomed Mater Res B Appl Biomater
January 2008
Native and heat denatured fibrinogen are the basis for various matrices used to establish hemostasis as well as for constructing biomedical devices. For example, fibrin microbeads (FMB) prepared by a heated ( approximately 70 degrees C) oil emulsion process were reported to be attractive to mesenchymal-type cells, such as fibroblasts, endothelial and smooth muscle cells, and useful for isolating mesenchymal stem cells from bone marrow. Here, we examined the solution properties of fibrinogen subjected to heat (47-60 degrees C).
View Article and Find Full Text PDF