Publications by authors named "Anna Hiu-Yi Wong"
Article Synopsis
- - CD137 is a co-stimulatory molecule that helps activated T cells, but in Hodgkin Lymphoma, it's also found on malignant Hodgkin Reed-Sternberg (HRS) cells, aiding their growth and evasion of the immune system.
- - The study highlights that HRS cells, which mostly come from B cells, ectopically express CD137, raising questions about how this transformation occurs, particularly during Epstein-Barr virus (EBV) infection.
- - The research reveals that EBV's latent membrane protein 1 (LMP1) triggers CD137 expression in HRS cells via the PI3K-AKT-mTOR pathway, with a significant correlation seen in nearly all CD137-positive HL cases.*
Article Synopsis
- The study introduces a rare form of Guillain-Barré syndrome involving small-fiber neuropathy, marked by prior infections, low reflexes, and specific changes in spinal fluid.
- Two patients were treated with either intravenous immunoglobulin or corticosteroids and showed improvement in their condition.
- The findings indicate that the immune system may temporarily target small nerve fibers, leading to symptoms similar to Guillain-Barré syndrome, as evidenced by specific antibody behavior and experimental models.
Objective: We report the clinical and serologic features of Japanese patients with chronic inflammatory demyelinating polyneuropathy (CIDP) displaying anti-neurofascin-155 (NF155) immunoglobulin G4 (IgG4) antibodies.
Methods: In sera from 533 patients with CIDP, anti-NF155 IgG4 antibodies were detected by ELISA. Binding of IgG antibodies to central and peripheral nerves was tested.
Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical improvement. On 30(th) day after onset, there was significantly higher frequency of axonal degeneration in the corticosteroids-treated rabbits than saline-treated rabbits.
View Article and Find Full Text PDFAutoimmune inflammatory neuropathies: updates in pathogenesis, diagnosis, and treatment.
Curr Opin Neurol
October 2015
Purpose Of Review: The present review aims at discussing the recent advances in pathogenesis, diagnosis, and treatment of major subtypes of autoimmune inflammatory neuropathies.
Recent Findings: Concerning pathogenesis, further evidence has proved that antibodies to nodal proteins are pathogenic in inflammatory neuropathies. The presence of these antibodies is related to distinctive clinical features.
Background: Because of the limitation of on-site neurology workforce, telestroke was implemented to overcome this barrier. We explored the efficacy and safety of intravenous (IV) stroke thrombolysis service by telestroke when neurologist was not available on-site.
Methods: From January 2009 to December 2012, we compared patients treated with IV stroke thrombolysis by telestroke in the form of telephone consultation with teleradiology, to patients treated after in-person assessment by the same team of neurologists in a regional hospital.
Sialylated IgG-Fc: a novel biomarker of chronic inflammatory demyelinating polyneuropathy.
J Neurol Neurosurg Psychiatry
March 2016
Article Synopsis
- The study investigates the role of IgG-Fc sialylation as a potential biomarker for disease activity in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).
- Researchers compared the glycosylation levels of serum IgG-Fc in untreated CIDP patients to those of healthy controls and among varying severities of CIDP, as well as before and after intravenous immunoglobulin (IVIG) treatment.
- Results showed reduced sialylation and galactosylation in CIDP patients, which correlated with disease severity, while sialylation levels increased post-IVIG treatment, suggesting that these measures could help in monitoring disease progress and treatment effectiveness.
A Spanish group recently reported that four patients with chronic inflammatory demyelinating polyneuropathy carrying IgG4 autoantibodies against contactin 1 showed aggressive symptom onset and poor response to intravenous immunoglobulin. We aimed to describe the clinical and serological features of Japanese chronic inflammatory demyelinating polyneuropathy patients displaying the anti-contactin 1 antibodies. Thirteen of 533 (2.
View Article and Find Full Text PDFCerebrospinal fluid (CSF) protein level, cell count, and its relationship to the timing of lumbar puncture were collected from patients with Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) from various Asian centers. A total of 507 patients with GBS were studied. Overall, 56% had elevated CSF protein level.
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