Publications by authors named "Anna Heydecke"
Background: This study sought to investigate associations between virulence factors and phylogeny in all neonatal Escherichia coli bloodstream infections from patients admitted to the neonatal intensive care unit at Uppsala University Hospital between 2005 and 2020.
Methods: A total of 37 E. coli isolates from 32 neonates were whole-genome sequenced and analyzed for virulence factors related to extraintestinal E.
BackgroundIn Sweden, information on seroprevalence of tick-borne encephalitis virus (TBEV) in the population, including vaccination coverage and infection, is scattered. This is largely due to the absence of a national tick-borne encephalitis (TBE) vaccination registry, scarcity of previous serological studies and use of serological methods not distinguishing between antibodies induced by vaccination and infection. Furthermore, the number of notified TBE cases in Sweden has continued to increase in recent years despite increased vaccination.
View Article and Find Full Text PDFPrediction of antibiotic resistance from whole genome sequence (WGS) data has been proposed. However, the performance of WGS data analysis for this matter may be influenced by the resistance mechanism's biology. This study compared traditional antimicrobial susceptibility testing with whole genome sequencing for identification of extended-spectrum beta-lactamases (ESBL) in a collection of 419 Escherichia coli isolates.
View Article and Find Full Text PDFArticle Synopsis
- Several proficiency testing (PT) and external quality assessment (EQA) schemes exist for evaluating laboratories' abilities to detect enteropathogenic bacteria, but they mainly focus on specific sectors like public health, food safety, or animal health.
- This study aims to assess the cross-sectoral detection capabilities of European laboratories for foodborne pathogens and propose recommendations for enhancing cross-sectoral PTs and EQAs in a One Health context.
- The results showed that while all participating laboratories recognized certain pathogens, many faced challenges with false negatives, especially with lower concentrations of target organisms, due to factors like smaller sample sizes and lack of enrichment methods.
During the ongoing COVID-19 pandemic, rapid and reliable detection of SARS-CoV-2 is important to enable proper care of patients and to prevent further transmission. The aim of this study was to evaluate the performance of the Roche SARS-CoV-2 Rapid Antigen Test (Ag-RDT) in an emergency care setting during a high pandemic period. The analytical performance of the Ag-RDT was compared to real-time reverse transcriptase polymerase chain reaction (rRT-PCR).
View Article and Find Full Text PDFBackground: Neisseria animaloris and Neisseria zoodegmatis, former CDC Group EF-4a and -4b, are considered to be rare zoonotic pathogens, usually associated with dog or cat bites. The aim of the study was to phenotypicaly characterize 13 EF-4 isolates from wound infections, determine their antibiotic susceptibility and to follow the clinical outcome of the patients.
Methods: 13 of the EF-4 isolates were cultured on agar plates.