Publications by authors named "Anna Hartley"
Background: Pancreatic ductal adenocarcinoma (PDAC) is a tumour entity with unmet medical need. To assess the therapeutic potential of oncolytic virotherapy (OVT) against PDAC, different oncolytic viruses (OVs) are currently investigated in clinical trials. However, systematic comparisons of these different OVs in terms of efficacy against PDAC and biomarkers predicting therapeutic response are lacking.
View Article and Find Full Text PDFInduced pluripotent stem cells (iPSCs) are a powerful tool for biomedical research, but their production presents challenges and safety concerns. Yamanaka and Takahashi revolutionised the field by demonstrating that somatic cells could be reprogrammed into pluripotent cells by overexpressing four key factors for a sufficient time. iPSCs are typically generated using viruses or virus-based methods, which have drawbacks such as vector persistence, risk of insertional mutagenesis, and oncogenesis.
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- The study looked at how women in the UK with HIV managed their pregnancies, especially those who can keep their virus levels very low without treatment.
- It compared pregnancies before and after 2012 when new guidelines changed how HIV was treated during pregnancy.
- Even with the changes in treatment, there were no new cases of HIV passed to babies, and the way babies were delivered varied quite a bit in recent years.
Article Synopsis
- Local government in England is important for improving health and reducing health inequalities in communities, but using research to make decisions is tough.
- Researchers studied a local authority to figure out how well they can work together and build research skills to help health efforts.
- They found that there's a need for a change in culture, better strategies for using research, and stronger connections between local government and universities to effectively address health issues.
Background: In pregnancy, reduction of HIV plasma viral load (pVL) for the prevention of vertical transmission is time-constrained. The study primary objective is to investigate factors associated with faster initial HIV RNA half-life decay when combination antiretroviral treatment (cART) is initiated in pregnancy.
Methods: This was a multicentre, retrospective, observational study, conducted in south England, United Kingdom, between August 2001 and February 2018.
Article Synopsis
- Autonomous rodent parvoviruses (PVs) are being studied as a safe and effective way to treat cancer because they can help the immune system fight tumors.
- Recent clinical trials show that while PVs have potential, their effectiveness isn't as high as what scientists hoped based on earlier studies.
- Researchers are working on improving these viruses and discovering how they interact with our cells to make PV treatments more personalized and powerful against cancer.
In April 2013, local authorities gained responsibility for commissioning sexual health services in England. With many services going out to tender and resultant change in services or service provider, there is anecdotal evidence that this has impacted on the education, training and morale of genitourinary medicine (GUM) trainees. The aim of this study was to evaluate the impact of tendering on GUM trainees.
View Article and Find Full Text PDFA number of macrocyclic squaramide-containing receptors (MSQs) have been designed and synthesised and their interaction with a range of inorganic anions was studied in solution by H NMR spectroscopy and ESI-HRMS. The binding data revealed remarkable binding of sulfate in aqueous mixtures from 0.5 to 50% v/v HO/DMSO-.
View Article and Find Full Text PDFBackground: Mass gatherings and large sporting events, such as the Olympics, may potentially pose a risk of increased sexually transmitted infection (STI) transmission and increase burden on local STI services. The objectives of this analysis were to assess whether the STI profile of Olympic visitors differed from that of the local STI clinic population and to investigate what impact these visitors had on local STI services.
Methods: Self-administered questionnaires (completed by 29,292 patients) were used to determine the visitor status of patients attending 20 STI clinics, between July 20, 2012, and September 16, 2012, in the host cities, London and Weymouth.