Publications by authors named "Anna Guitart-Solanes"
Article Synopsis
- Pericentric heterochromatin (PCH) is crucial for genome integrity, and disruptions in PCH are linked to cancer and aging.
- HP1α, β, and γ are proteins associated with heterochromatin that help maintain PCH structure through their interactions with histone modifications.
- The histone variant H2A.Z plays an important yet poorly understood role in PCH, influencing its stability and organization, particularly through its interactions with HP1 isoforms, thereby impacting genome stability and the potential development of chromosome defects.
The Sirtuin family of NAD+-dependent enzymes plays an important role in maintaining genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). The role of one of them, SIRT1, is intriguing as it seems to have a general regulatory role in the DNA damage response (DDR) that has not yet been addressed.
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