Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses.

Shallow water equations for equatorial tsunami waves.

We present derivations of shallow water model equations of Korteweg-de Vries and Boussinesq type for equatorial tsunami waves in the -plane approximation and discuss their applicability.This article is part of the theme issue 'Nonlinear water waves'.

Spectral stability of periodic waves in the generalized reduced Ostrovsky equation.

We consider stability of periodic travelling waves in the generalized reduced Ostrovsky equation with respect to co-periodic perturbations. Compared to the recent literature, we give a simple argument that proves spectral stability of all smooth periodic travelling waves independent of the nonlinearity power. The argument is based on the energy convexity and does not use coordinate transformations of the reduced Ostrovsky equations to the semi-linear equations of the Klein-Gordon type.

Effects of clobazam for treatment of refractory status epilepticus.

Background: Clobazam (CLB) is a well characterized antiepileptic drug (AED) that differs from other benzodiazepines by its basic chemical structure and pharmacodynamic properties. Only one previous study examined the efficacy of CLB as add-on therapy in refractory status epilepticus (RSE).

Methods: We analyzed RSE episodes treated in our institution between 2001 and 2012.

Association of seizure duration and outcome in refractory status epilepticus.

The aim of the study was to identify factors influencing long-term outcome and to evaluate the prognostic power of the Status Epilepticus Severity Score (STESS) in refractory status epilepticus (RSE). We retrospectively extracted data on baseline characteristics, RSE details, and hospital course including complications from all patients treated for RSE in our institution between January 2001 and January 2013. Functional outcome was assessed using the modified Rankin Scale (mRS) and was defined as good when either RSE did not lead to functional decline or when the resulting mRS score was 2 or below.

Traveling surface waves of moderate amplitude in shallow water.

We study traveling wave solutions of an equation for surface waves of moderate amplitude arising as a shallow water approximation of the Euler equations for inviscid, incompressible and homogeneous fluids. We obtain solitary waves of elevation and depression, including a family of solitary waves with compact support, where the amplitude may increase or decrease with respect to the wave speed. Our approach is based on techniques from dynamical systems and relies on a reformulation of the evolution equation as an autonomous Hamiltonian system which facilitates an explicit expression for bounded orbits in the phase plane to establish existence of the corresponding periodic and solitary traveling wave solutions.