A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models.

Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology regardless of the underlying genetic lesion are desirable due to the diversity of mutations found in such diseases. We tested a systems pharmacology-based strategy that suppresses intracellular cAMP and Ca2+ activity via G protein-coupled receptor (GPCR) modulation using tamsulosin, metoprolol, and bromocriptine coadministration.

Mechanical Joining of Fibre Reinforced Polymer Composites to Metals-A Review. Part I: Bolted Joining.

As the fibre reinforced plastic composites gain larger and larger share in industry, the problem of joining them with metal elements becomes significant. The current paper is the first part of the literature review, which gathers and evaluates knowledge about methods suitable for mechanical joining of composite and metal elements. This paper concerns bolted joining, because this method of mechanical joining is widely used for joining composite materials.

Mechanical Joining of Fibre Reinforced Polymer Composites to Metals-A Review. Part II: Riveting, Clinching, Non-Adhesive Form-Locked Joints, Pin and Loop Joining.

As fiber reinforced plastic composites gain an increasingly larger share in aerospace structures, the problem of joining them with metal elements becomes significant. The current paper is the second part of the literature review, which gathers and evaluates knowledge about methods suitable for the mechanical joining of composite and metal elements. This paper reviews the joining methods other than bolted joining, which are discussed in the first part of the review, namely self-piercing riveting, friction riveting, clinching, non-adhesive form-locked joints, pin joints, and loop joints.

[Evaluation of selected immunocompetent cells expression in gastric mucosa in children with Helicobacter pylori infection before and after eradication treatment--a preliminary study].

Introduction: Helicobacter pylori infection activates local immunological response and causes mononuclear cells infiltration in the gastric mucosa. On this account the studies on lymphocyte subpopulations in the gastric mucosa in children during Helicobacter pylori infections are inconsistent. It has been shown that the morphological status of gastric mucosa in children with Helicobacter pylori infection is different than in adult patients.

[Erythema nodosum of tuberculous etiology in a 18 months old girl].

The authors report a case of an 18-months old girl with primary tuberculosis, where erythema nodosum was the main symptom. She received BCG vaccination on the first day of life according to the Polish vaccination programme. Although there was no postvaccinal scar when she was 12 months old, she was not revaccinated.

[Antibiotics in lower respiratory tract infection].

The Aim Of The Study: Comparison of clinical outcome of lower respiratory tract infections in small children treated or not treated with antibiotics.

Material And Methods: Eighty seven children aged from 2 months to 5 years admitted to hospital with mild to moderate bronchitis and/or pneumonia were randomly allocated to one of two groups: group A children were treated with antibiotics and group B patients were not. The children remained under close clinical observation.