Publications by authors named "Anna Elliot"
Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported. From genome-wide association study (GWAS) analysis of 307,291 SNPs in 986 TGCT cases and 4,946 controls, we selected for follow-up 694 SNPs, which we genotyped in a further 1,064 TGCT cases and 10,082 controls from the UK.
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- Copy number variants (CNVs) are significant in human genetic diversity and may influence susceptibility to common diseases.
- A study analyzed around 19,000 individuals for associations between CNVs and eight common diseases using a specialized array that covered many polymorphic CNVs.
- The findings indicated that while some CNV loci were linked to diseases, they largely overlap with previously identified single nucleotide polymorphisms (SNPs), suggesting that common CNVs may not play a major role in the genetic underpinnings of these diseases.