Publications by authors named "Anna E Zurawska"
Article Synopsis
- Circular RNA (circRNA) is a new type of non-coding RNA that influences microRNA activity and is linked to the mechanisms of multiple sclerosis (MS).
- A study examined circRNA profiles in the blood of 20 patients with relapsing-remitting MS and 10 healthy controls, identifying 246 circRNAs that are significantly downregulated in MS patients.
- Validation of two specific circRNAs, hsa_circRNA_101145 and hsa_circRNA_001896, showed their levels decrease during MS remission, pointing to potential roles in critical pathways related to oxidative stress and blood-brain barrier function.
Multiple Sclerosis: circRNA Profile Defined Reveals Links to B-Cell Function.
Neurol Neuroimmunol Neuroinflamm
September 2021
Article Synopsis
- The study aimed to analyze the circular RNA (circRNA) profiles in patients with relapsing-remitting multiple sclerosis (RRMS) compared to healthy individuals, focusing on immune cells.
- Researchers utilized hybridization microarray technology to examine nearly 14,000 circRNAs in blood samples from 20 RRMS patients and 10 healthy controls, validating findings with a larger cohort.
- The results identified 914 circRNAs differentially expressed between RRMS patients and controls, with three specific circRNAs significantly elevated during disease relapse, suggesting potential roles in B-cell dysfunction and as biomarkers for monitoring RRMS activity.