Weight Gain in People with HIV: The Role of Demographics, Antiretroviral Therapy, and Lifestyle Factors on Weight.

We explored factors associated with weight gain among people with HIV (PWH) on antiretroviral therapy (ART) at The Ohio State University Wexner Medical Center (OSUWMC). This was a retrospective cohort study of adult PWH on ART for ≥3 months. Patients with CD4 T cell count <200 cells/mm, viral load >200 copies/mL, history of malignancy, or pregnancy were excluded.

Tfap2a is a novel gatekeeper of nephron differentiation during kidney development.

Renal functional units known as nephrons undergo patterning events during development that create a segmental array of cellular compartments with discrete physiological identities. Here, from a forward genetic screen using zebrafish, we report the discovery that transcription factor AP-2 alpha () coordinates a gene regulatory network that activates the terminal differentiation program of distal segments in the pronephros. We found that acts downstream of Iroquois homeobox 3b (), a distal lineage transcription factor, to operate a circuit consisting of , and genes encoding solute transporters that dictate the specialized metabolic functions of distal nephron segments.