Publications by authors named "Anna E Bastiaansen"
Introduction: Genetic predisposition to autoimmune encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDAR) is poorly understood. Given the diversity of associated environmental factors (tumors, infections), we hypothesized that human leukocyte antigen () and killer-cell immunoglobulin-like receptors (), two extremely polymorphic gene complexes key to the immune system, might be relevant for the genetic predisposition to anti-NMDAR encephalitis. Notably, KIR are chiefly expressed by Natural Killer (NK) cells, recognize distinct HLA class I allotypes and play a major role in anti-tumor and anti-infection responses.
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- The study validated the clinical criteria for autoimmune encephalitis (AE) proposed in 2016 and identified common conditions that can mimic AE, leading to misdiagnoses.
- Out of 239 patients, 44% were diagnosed with AE, while 46% had mimicking conditions, highlighting the complexity of accurately diagnosing AE in patients with similar symptoms.
- The results showed varying sensitivity and specificity for different AE criteria, with the new criteria for probable anti-LGI1 encephalitis having a notable sensitivity of 66% and a high specificity of 96%.
A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I.
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