Publications by authors named "Anna Duszewska"

Water pollution exerts a negative impact on the health of both women and men, inducing hormonal changes, accelerating aging, and consequently leading to the premature onset of age-related health problems. Water pollutants can in general be classified as chemical (both organic and inorganic), physical, and biological agents. Certain chemical pollutants have been found to disrupt hormonal balance by blocking, mimicking, or disrupting functions within the intricate homeostasis of the human body.

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Worldwide, cognitive decline and dementia are becoming one of the biggest challenges for public health. The decline in cognition and the development of dementia may be caused by predisposing or trigger factors. There is no consensus over whether the drop in estrogen levels after menopause is a risk factor for cognitive decline and dementia.

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In Brief: A genetic, epigenetic, and environmental association exists between oxidative stress (OS) and polycystic ovary syndrome (PCOS), expressed in a multifaceted clinical profile. This review summarizes and discusses the role of OS in the pathogenesis of PCOS syndrome, focusing on metabolic, reproductive, and cancer complications.

Abstract: Oxidative stress (OS), an imbalance between oxidants and antioxidants in cells, is one of many factors playing essential roles in the pathogenesis of polycystic ovary syndrome (PCOS).

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Background: The wisent (Bison bonasus) is a species that has undergone a population bottleneck. Homozygosity is prevalent within the population and may have a negative impact on semen quality in wisent bulls. Semen samples containing a large amount of functionally and morphologically impaired or dead spermatozoa have lower tolerance for cryopreservation process.

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The wisent, or European bison (), belongs to the same family (Bovidae) as the American bison and domestic cattle. The wisent is the largest mammal in Europe, and is called the "Forest Emperor". The wisent is listed as "Vulnerable" on the IUCN Red List, and is protected by international law.

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HPV is one of the diseases of civilization that causes cervical cancer, among other diseases. For this reason, a vaccination program has been introduced worldwide for preadolescent, sexually inactive seronegative girls. However, the decision to vaccinate young girls must be made by the parents.

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women. It is characterized by chronic anovulation, hyperandrogenism, and the presence of polycystic ovary in ultrasound examination. PCOS is specified by an increased number of follicles at all growing stages, mainly seen in the preantral and small antral follicles and an increased serum level of Anti-Müllerian Hormone (AMH).

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The transition to menopause, usually occurring between the ages of 40 and 55, is a time when women are particularly vulnerable. When preexisting mental illness is present, symptoms are often amplified during this period. Moreover, women with mental illnesses experience menopausal symptoms similarly to healthy women.

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Article Synopsis
  • - Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 5-10% of women of reproductive age, characterized by symptoms like irregular ovulation, high levels of male hormones, and polycystic ovaries.
  • - PCOS can lead to significant health issues such as obesity, insulin resistance, and an increased risk of type 2 diabetes, cardiovascular diseases, and chronic inflammation, which worsens under conditions like obesity and hyperinsulinemia.
  • - Inflammation markers like C-reactive protein and various cytokines are found at higher levels in women with PCOS, indicating an underlying chronic inflammatory state that may contribute to other health problems.
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  • - The study assessed how higher temperatures affect bovine oviduct epithelial cells (BOECs), focusing on two proteins: heat shock protein 70 (HSP70) for cell defense and oviduct specific glycoprotein 1 (OVGP1) for embryo support.
  • - BOECs were tested at normal (38.5°C) and elevated temperatures (41°C) for 168 hours, revealing that while BOECs remained viable, embryo development suffered negatively at higher temperatures.
  • - Increased HSP70 and decreased OVGP1 expression were observed at elevated temperatures, but co-culturing with embryos helped maintain some OVGP1 levels, highlighting the complex relationship between embryo development and oviduct conditions under
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  • The study aimed to explore how aglepristone affects the ovaries and uterus of non-pregnant bitches, focusing on steroid hormone levels and receptor expression during placentation.
  • Fourteen bitches received either aglepristone or saline, and their hormonal levels were checked while their reproductive tissues were analyzed for structural changes and receptor activity.
  • Results indicated lower progesterone levels due to aglepristone, alongside increased estrogen receptor expression in the endometrium, which was linked to inflammation and thicker uterine tissues compared to the control group.
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TSG-6 is an ~35 kDa glycoprotein belonging to the hyaluronan binding family. Its expression is induced as a result of an inflammatory condition and during ovulation. TSG-6 is a crucial protein engaged in extracellular matrix synthesis and organization of cumulus-oophorus-complexes (COCs) in preovulatory ovarian follicles.

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Most transgenic domestic animals are generated by direct microinjection of DNA fragments into zygote pronuclei. It has generally been assumed that the majority of integration events should occur prior to the first round of chromosomal DNA replication. The aim of this study was to investigate the expression of GFP in bovine preimplantation embryos by using a gfp reporter gene consisting of chicken beta-actin promoter, the CMV-IE enhancer, gfp cDNA (EGFP) (732 bp) and rabbit beta-globin polyadenylation sequences.

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