Publications by authors named "Anna Doshina"
The amyloid precursor protein (APP) has been extensively studied as the precursor of the β-amyloid (Aβ) peptide, the major component of the senile plaques found in the brain of Alzheimer's disease (AD) patients. However, the function of APP per se in neuronal physiology remains to be fully elucidated. APP is expressed at high levels in the brain.
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- Scientists are trying to understand how a special protein called PPARα helps improve brain function when another protein called RXR is activated.
- They found that when RXR is turned on, it helps a part of the brain called the hippocampus work better, especially in male mice with learning problems.
- The study shows that male mice have more PPARα than female mice, meaning the effects of these proteins are different based on the mouse's sex.
The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations regulated by Na-K-2Cl cotransporter 1 (NKCC1) and neuronal K-Cl cotransporter 2 (KCC2), allowing entrance and efflux of chloride, respectively. Modifications in NKCC1 and KCC2 expression during maturation of cortical cells induce a shift in GABAergic signaling.
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