The impact of non-structural carbohydrates (NSC) concentration on yield in Prunus dulcis, Pistacia vera, and Juglans regia.

Successful yield in orchards is the culmination of a series of events that start with plants entering dormancy with adequate energy reserves (non-structural carbohydrates; NSC). These NSC are responsible for the maintenance of activities during dormancy and extending onto the period of activeness. Using multi-year yield information and monthly NSC content in twigs, we show that high levels of carbohydrate in Prunus dulcis, Pistachio vera, and Juglans regia during the winter months are indeed associated with high yield, while high levels of the NSC in late summer often correlate with low yield.

No time to rest: seasonal dynamics of non-structural carbohydrates in twigs of three Mediterranean tree species suggest year-round activity.

Perennial plants in temperate climates evolved short and long-term strategies to store and manage reserves in the form of non-structural carbohydrates (NSC; soluble sugars (SC) and starch (St)). NSC storage allows plants to survive seasonal periods of photosynthetic inactivity (dormancy). To study year-to-year seasonal patterns of trees' NSC dynamics that control phenology and yields, we established a large scale, multi-year study called the "Carbohydrate Observatory" using a citizen science approach with ~ 590 sites throughout the Central Valley of California.

Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus.

Stress is a potent environmental factor that can confer potent and enduring effects on brain structure and function. Exposure to stress during early life (ELS) has been linked to a wide range of consequences later in life. In particular, ELS exerts lasting effects on neurogenesis in the adult hippocampus, suggesting that ELS is a significant regulator of adult neural stem cell numbers and function.

Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences.

Whilst it is universally accepted that the energy support of the brain is glucose, the form in which the glucose is taken up by neurones is the topic of intense debate. In the last few decades, the concept of lactate shuttling between glial elements and neural elements has emerged in which the glial cells glycolytically metabolise glucose/glycogen to lactate, which is shuttled to the neural elements via the extracellular fluid. The process occurs during periods of compromised glucose availability where glycogen stored in astrocytes provides lactate to the neurones, and is an integral part of the formation of learning and memory where the energy intensive process of learning requires neuronal lactate uptake provided by astrocytes.

Factors affecting quality of life in patients experiencing facial disfigurement due to surgery for head and neck cancer.

Aim:: to explore the factors affecting quality of life in patients who experience facial disfigurement resulting from surgical treatment for head and neck cancer.

Background:: the number of people diagnosed with head and neck cancers has been rising over the past 30 years. This, combined with the improved survivorship of cancer patients, has led to a need to understand how these patients adapt to the physical, social and emotional toll of cancer and facial disfigurement and how these affect quality of life.

The phyllochron of well-watered and water deficit mature peach trees varies with shoot type and vigour.

The branch construction of trees is based on phytomers, repetitive subunits defined as node + leaf + axillary meristem + internode. The rate at which phytomers are added to a shoot is termed the phyllochron, which is determined by genetics, endogenous regulation and environmental conditions. The phyllochron is fundamental to understanding the growth of plants.

Effects of therapeutic goal management (TGM) on treatment attendance and drug abstinence among men with co-occurring substance use and axis I mental disorders who are homeless: results of the Birmingham EARTH program.

Purpose: This study describes the implementation and impact of Therapeutic Goal Management (TGM) in a Substance Abuse and Mental Health Services Administration (SAMHSA)-sponsored demonstration project entitled Enhanced Addiction Recovery through Housing (EARTH).

Participants: The sample included 28 male participants followed at six months who completed some treatment. Forty-three percent were Caucasian, and 57% were African American.

Phloem loading, plant growth form, and climate.

Plasmodesmatal frequencies in the phloem of leaf minor veins vary considerably, suggesting that photoassimilate is loaded into the phloem by different strategies. The ecophysiological basis for multiple loading types is unknown. We updated the analysis of van Bel and Gamalei (Plant Cell Environ 15: 265-270, 1992) with more current phylogenetic data and by treating separately two symplastic loading types, those that load actively by polymer trapping (synthesis of raffinose family oligosaccharides--RFOs), and those that load passively, by diffusion.

Stimulant drug treatment in childhood-onset schizophrenia with comorbid ADHD: an open-label case series.

The administration of psychostimulants to children with psychotic symptoms is controversial. This study reports the stimulant drug response of 5 children, aged 8-15 years, with childhood-onset schizophrenia (COS) and comorbid attention deficit hyperactivity disorder (ADHD). Four COS inpatients were given stimulants for comorbid ADHD after stabilization of psychosis on antipsychotic medication.

A double antibody radioimmunoassay for the determination of XV459, the active hydrolysis metabolite of roxifiban, in human plasma.

A radioimmunoassay (RIA) was developed for the determination of XV459, the active hydrolysis metabolite of the oral prodrug roxifiban (DMP 754), in human plasma. XV459 is a potent antagonist of the glycoprotein IIb/IIIa receptor. The method utilizes a competitive double antibody format employing an 125I-labeled XV459 analogue tracer which competes with XV459 for antibody binding sites and a second antibody precipitation step to separate antibody bound analyte from free analyte.