Exploring protein relative relations in skeletal muscle proteomic analysis for insights into insulin resistance and type 2 diabetes.

The escalating prevalence of insulin resistance (IR) and type 2 diabetes mellitus (T2D) underscores the urgent need for improved early detection techniques and effective treatment strategies. In this context, our study presents a proteomic analysis of post-exercise skeletal muscle biopsies from individuals across a spectrum of glucose metabolism states: normal, prediabetes, and T2D. This enabled the identification of significant protein relationships indicative of each specific glycemic condition.

ITree: a user-driven tool for interactive decision-making with classification trees.

Motivation: ITree is an intuitive web tool for the manual, semi-automatic, and automatic induction of decision trees. It enables interactive modifications of tree structures and incorporates Relative Expression Analysis for detecting complex patterns in high-throughput molecular data. This makes ITree a versatile tool for both research and education in biomedical data analysis.

The SnRK2.10 kinase mitigates the adverse effects of salinity by protecting photosynthetic machinery.

SNF1-Related protein kinases Type 2 (SnRK2) are plant-specific enzymes widely distributed across the plant kingdom. They are key players controlling abscisic acid (ABA)-dependent and ABA-independent signaling pathways in the plant response to osmotic stress. Here we established that SnRK2.

Alterations in Circulating MicroRNAs and the Relation of MicroRNAs to Maximal Oxygen Consumption and Intima-Media Thickness in Ultra-Marathon Runners.

The impact of long-term training on cardiovascular disease (CVD) is not clear. Carotid intima-media thickness (CIMT) test is recommended as a useful measure to diagnose the early stages of atherosclerosis. MicroRNAs (miRNAs) are altered due to endurance exercise and can be promising biomarkers of pathophysiological changes.

Epicardial Adipose Tissue and Cardiovascular Risk Assessment in Ultra-Marathon Runners: A Pilot Study.

Epicardial adipose tissue (EAT) volume is associated with cardiovascular disease (CVD). Data regarding the influence of extremely intensive training on CVD are scarce. We compared EAT volume among ultra-marathon runners and in the sedentary control group, and assessed the correlations between EAT and risk factors of coronary artery disease (CAD).

The Effect of the Ultra-Marathon Run at a Distance of 100 Kilometers on the Concentration of Selected Adipokines in Adult Men.

Pro-inflammatory adipokines have a multifunctional role in adipogenesis, angiogenesis, glucose homeostasis, and inflammation. The aim of the present study is to evaluate the effect of running a 100 km ultra-marathon on serum levels of two adipokines: resistin and chemerin. Fifteen male participants complete a medical questionnaire and their body composition is assessed.

Acute Effects of a Static Vs. a Dynamic Stretching Warm-up on Repeated-Sprint Performance in Female Handball Players.

This randomized cross-over study examined the effects of typical static and dynamic stretching warm-up protocols on repeated-sprint performance. Thirteen young female handball players performed a 5 min aerobic warm-up followed by one of three stretching protocols for the lower limbs: (1) static stretching, (2) dynamic-ballistic stretching, and (3) no stretching before performing five all-out sprints on a cycle ergometer. Each protocol was performed on a different occasion, separated by 2-3 days.

Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon.

Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition.

Cardiovascular magnetic resonance with parametric mapping in long-term ultra-marathon runners.

Purpose: There is a direct reverse dose-effect relationship between the amount of physical activity and cardiovascular risk. It is unknown whether this is true for extreme, persistent endurance training. The aim of the study was to assess structural changes of the heart in long-time ultra-marathon runners with special focus on myocardial fibrosis using parametric mapping.

Strength Abilities in Men 50+ as an Effect of Long-Distance Run Training.

The aim of this study was to evaluate the effect of long-term running training on muscle strength of men aged 50 and above. The study involved two groups of men aged 50 and above: physically active (E, = 34) and inactive (NE, = 20). Body composition was assessed with the electrical bioimpedance method.

Accuracy of Impedance Cardiography for Hemodynamic Assessment During Rest and Exercise in Wheelchair Rugby Players.

: The aim of the study was to analyze the accuracy of impedance cardiography (ICG) for hemodynamic assessment in wheelchair rugby players during rest and exercise. : The study included 21 players (mean age 33.0 ± 5.

Left ventricular hypertrophy in middle-aged endurance athletes: is it blood pressure related?

Both regular physical activity and hypertension may be related to increased myocardial thickness, but the interplay between these two factors in causing cardiac remodeling in athletes is still a matter of debate. The aim of this study was to analyze the relation between resting and peak exercise blood pressure (BP) and myocardial hypertrophy in healthy middle-aged amateur endurance athletes. The study included 30 male, long-term athletes (mean age 40.

Effects of Short-Term Plyometric Training on Physical Performance in Male Handball Players.

The aim of this study was to compare the effects of plyometric and jump training on physical performance in young male handball players. Twenty-six young male handball players were divided into two sub-groups to perform a five-week pre-season training programme supplemented with two ground-reactive protocols with an equal number of jumping exercises referred as to ground contacts: plyometric training (PLY; n = 14) and standard jump training (CON; n = 12). Before and after training, repeated sprint ability (RSA), jumping ability (JA), maximal oxygen uptake (VO2max) and aerobic power at the anaerobic threshold (PAT) were measured.

Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a']diisoquinoline Derivative and Its Synergistic Action with in Human Gastric Cancer Cells.

Many studies have shown that naturally occurring compounds may support prevention and treatment of various diseases, including cancer. Pharmacological investigations revealed a wide spectrum of biological activities. Combining natural compounds together with synthetic drugs may increase the anticancer activity and limit severe side effects of such a treatment and may be an alternative to monotherapy.

Changes in Anthropometry and Selected Metabolic Parameters in Young Men During Their First Year of Study at a University of Physical Education.

This study aims to determine main health-related anthropometric and metabolic parameters in young physically active male students in their first year of study. Sixty one male students from a Polish university of physical education were studied twice-at the beginning of their first and second academic years. Body weight, height, waist circumference, and body composition were measured.

Synthesis and antimicrobial activity of chiral quaternary -spiro ammonium bromides with 3',4'-dihydro-1'H-spiro[isoindoline-2,2'-isoquinoline] skeleton.

A new class of highly functionalized tetrahydroisoquinolines with a quaternary carbon stereocenter was synthesized starting from an easily accessible L-tartaric acid. Nine strains of bacteria () were used for the determination of minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of synthesized compounds. The influence of analyzed compounds on viability and induction of apoptosis in human skin fibroblasts was determined.

Biological evaluation of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives as potent anticancer agents.

In this study, we evaluated the cytotoxic activity and antiproliferative potency of novel octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives (1-7) in MCF-7 and MDA-MB-231 breast cancer cell lines. Annexin V binding assay and disruption of the mitochondrial potential were performed to determine apoptosis. The activity of caspases 3, 8, 9, and 10 was measured after 24 h of incubation with tested compounds to explain detailed molecular mechanism of induction of apoptosis.

Cardiovascular risk reduction in sedentary postmenopausal women during organised physical activity.

Background: Cardiovascular (CV) diseases are a major cause of death in elderly women. Aerobic training improves component CV risk factors. Long-term, higher-intensity, group-based and home-based exercise training has been shown to improve exer-cise performance.

Synergistic action of cisplatin and echistatin in MDA-MB-231 breast cancer cells.

The aim of our study was to determine whether the use of cisplatin in the presence echistatin in MDA-MB-231 breast cancer cells leads to a reduction of toxic effects associated with the use of cisplatin. The expression of β-integrin and insulin-like growth factor 1 receptor (IGF-IR), signaling pathway protein expression: protein kinase B (AKT), mitogen-activated protein kinases (ERK1/ERK2), nuclear factor kappa B (NFκB), and caspase-3 and -9 activity was measured after 24 h of incubation with tested compounds to explain detailed molecular mechanism of induction of apoptosis. The viability of MDA-MB-231 breast cancer cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

Effects of aerobic interval training versus continuous moderate exercise programme on aerobic and anaerobic capacity, somatic features and blood lipid profile in collegate females.

Introduction: Regular physical activity has many positive health benefits, including reducing the risk of cardiovascular diseases, metabolic diseases and some cancers, as well as improving the quality of life. objectives. The aim of the study was to examine the effects of 8-week aerobic interval cycle exercise training (AIT) compared to continuous cycle exercises of moderate intensity (CME) on the aerobic and anaerobic capacity, somatic features and lipid profile.

Relationship between the percentage of body fat and surrogate indices of fatness in male and female Polish active and sedentary students.

Background: Limited data have indicated that body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR) and waist to height ratio (WHtR) of athletes and young adults provide misleading results concerning body fat content. This study was aimed at the evaluation of the relationship between different surrogate indices of fatness (BMI, WC, WHR, WHtR and body adiposity index (BAI)) with the percentage of body fat in Polish students with respect to their sex and physical activity.

Methods: A total of 272 students volunteered to participate in the study.

Variability in HOMA-IR, lipoprotein profile and selected hormones in young active men.

Resistance to insulin actions is contributing to many metabolic disturbances. Such factors as age, sex, nutrition, body fat, and physical activity determine body insulin resistance. Present study attempted to asses insulin resistance and its metabolic effects with respect to energy intake in young, lean, and active men.

[Elaboration of chemotaxonomical detection method of presence Legionella pneumophila cultures in water samples by GC-MS technique].

The aim of this study was elaboration of chemotaxonomical detection method of presence Legionella pneumophila cultures in water samples. In research, the profile of ester-linked fatty acids were specified, which are situated in the cell wall of the model bacteria cultures Legionella pneumophila 33152, which originate from ATCC collection Philadelphia 1 type. The profile were applied as a standard to detection L.

Plasma homocysteine levels, physical activity and macronutrient intake in young healthy men.

Introduction: It is well documented that high blood homocysteine (Hcy) levels possibly contribute to insulin resistance through the induction of resistin and inhibition of adiponectin expression in mouce adipose tissue in vitro. Additionally, in humans, hyperhomocysteinemia has been recognized as an independent risk factor for cardiovascular disease (CVD).

Aim Of The Study: Our study aimed at the evaluation of the relationship between total plasma Hcy levels and physical activity, cardiorespiratory fitness and dietary habits in young healthy men.

Effect of pathological tooth wear on the content of calcium, magnesium, zinc and phosphate in human dentin.

Aim: To compare the mineral content of the dentin of worn versus unworn teeth.

Material And Methods: Coronal dentin samples were collected from twenty one premolar teeth extracted for prosthetic or periodontal indications, including 11 intact teeth and 10 teeth with a significant occlusal wear. Samples were placed in concentrated nitric acid and diluted 500 times for the analysis of calcium and magnesium content and 11 times for the analysis of zinc.