Publications by authors named "Anna Cristina Gervasio de Brito Lutaif"
Article Synopsis
- The study focuses on determining how prevalent and impactful DNA viral infections are in children with nephrotic syndrome (NS), specifically looking at various viruses like Epstein-Barr and cytomegalovirus.
- Researchers conducted a prospective study involving 35 NS patients aged 1 to 18, monitoring viral presence in plasma and urine over an average of 266 days, finding that 31.4% had active viral infections.
- Notably, HCMV was the most common infection linked to increased proteinuria and hospitalization rates, highlighting its significance in worsening NS in pediatric patients.
APOL1 in an ethnically diverse pediatric population with nephrotic syndrome: implications in focal segmental glomerulosclerosis and other diagnoses.
Pediatr Nephrol
August 2021
Background: APOL1 high-risk genotypes (HRG) are associated with increased risk of kidney disease in individuals of African ancestry. We analyzed the effects of APOL1 risk variants on an ethnically diverse Brazilian pediatric nephrotic syndrome (NS) cohort.
Methods: Multicenter study including 318 NS patients, categorized as progressors to advanced CKD [estimated glomerular filtration rate (eGFR)] < 30 mL/min/1.
High-throughput techniques such as whole-exome sequencing (WES) show promise for the identification of candidate genes that underlie Mendelian diseases such as nephrotic syndrome (NS). These techniques have enabled the identification of a proportion of the approximately 54 genes associated with NS. However, the main pitfall of using WES in clinical and research practice is the identification of multiple variants, which hampers interpretation during downstream analysis.
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