A case of anaphylaxis is reported in the course of a prick by prick with Lupinus albus and roasted peanut in a 20-year-old woman. We focused on some main topics. First of all it seems important to underscore the potential risks connected to the practice of the prick-by-prick with fresh foods in allergic patients, especially when testing cross-reactive substances, such as White Lupine, peanuts, or soy.
View Article and Find Full Text PDFBackground: Up to now very few data on allergic sensitization to rodent allergens in Western Europe and Italy are available, and there are no information at district level.The aim of this report was to investigate clinical significance and characteristics of allergic sensitization to mouse/rat (M/Rt) allergens in atopic subjects living in Campania district (Southern Italy).
Methods: Allergists from the whole Campania district were required to report the results of skin prick tests of at least 100 consecutive subjects.
Aging is a multifactorial process resulting in damage of molecules, cells, and tissues. It has been demonstrated that the expression and activity of antioxidant systems (SOD, HSPs) are modified in aging, with reduced cell ability to counteract the oxidant molecules, and consequent weak resistance to ROS accumulation. An important mechanism involved is represented by sirtuins, the activity of which is reduced by aging.
View Article and Find Full Text PDFInt Arch Allergy Immunol
September 2009
The gene product of the steel locus is a growth factor for mast cells and a ligand for the c-kit proto-oncogene receptor, a member of the tyrosine kinase receptor class of oncogenes. We studied the effect of recombinant human c-kit receptor ligand stem cell factor (rhSCF) on the release of preformed (histamine) and de novo synthesized mediators [prostaglandin D2 (PGD2) and peptide leukotriene C4 (LTC4)] from mast cells purified from human lung parenchyma (HLMC). rhSCF (0.
View Article and Find Full Text PDFInt Arch Allergy Immunol
September 2009
Cyclosporin A (CsA) a cyclic undecapeptide extracted from Tolypodadium inflatum Gams, is effective in the prevention/treatment of graft rejection and in an increasing number of autoimmune and inflammatory disorders. The immunosuppressive effect of CsA was initially attributed to inhibition of lymphokine mRNA transcription. We have demonstrated that pharmacological concentrations of CsA (10-100 ng/ml) also inhibit the in vitro immunologic release of preformed (histamine) and de novo synthesized (leukotriene C4 and prostaglandin D2) mediators of inflammatory reactions from human basophils and mast cells.
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