Publications by authors named "Anna Christina Tojal da Silva"
Disseminated sporotrichosis with osteoarticular involvement in a patient with acquired immunodeficiency syndrome: a case report.
Rev Soc Bras Med Trop
December 2024
Sporotrichosis is caused by fungi belonging to the genus Sporothrix, and is generally acquired by traumatic inoculation. A 26-year-old man developed pustular lesions and a 6-kg weight loss after developing a lesion on his right hand 6 months previously. He was diagnosed with acquired human immunodeficiency syndrome (AIDS) and disseminated sporotrichosis cultures of bone and muscle biopsy and blood samples grew Sporothrix schenckii.
View Article and Find Full Text PDFEfficacy and safety of Ixekizumab vs. low-dose IL-2 vs. Colchicine vs. standard of care in the treatment of patients hospitalized with moderate-to-critical COVID-19: A pilot randomized clinical trial (STRUCK: Survival Trial Using Cytokine Inhibitors).
Rev Soc Bras Med Trop
April 2023
Background: Cases of coronavirus disease 2019 (COVID-19) requiring hospitalization continue to appear in vulnerable populations, highlighting the importance of novel treatments. The hyperinflammatory response underlies the severity of the disease, and targeting this pathway may be useful. Herein, we tested whether immunomodulation focusing on interleukin (IL)-6, IL-17, and IL-2, could improve the clinical outcomes of patients admitted with COVID-19.
View Article and Find Full Text PDFSensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics.
Front Chem
November 2021
Article Synopsis
- Neurocryptococcosis, a type of meningoencephalitis, is treated with a combination of amphotericin B (AmB) and fluconazole.
- The study developed sensitive LC-MS/MS methods to measure AmB levels in cerebrospinal fluid (CSF) and plasma during treatment, successfully validating these methods for different sample types.
- Results showed that AmB concentrations in CSF were significantly lower than in plasma, with pharmacokinetic analyses highlighting changes in drug clearance and distribution throughout the treatment period.
Objective: Information on Leishmania species diversity in western Brazilian Amazon and the clinical picture of human cutaneous leishmaniasis it causes is scarce. We describe clinical findings, diagnostic procedures and identification of Leishmania species in patients from that region.
Methods: The sample consisted of 50 patients, prospectively evaluated for epidemiological and clinical characteristics by means of a structured questionnaire.