Publications by authors named "Anna Christina Schacht"
Article Synopsis
- Patients with Lewy body diseases show varying levels of brain metabolism reduction, which may be linked to synaptic degeneration, though the exact reasons for this decline remain unclear.
- The study aimed to explore if local synaptic loss in the cortex correlates with decreased brain metabolism by using PET scans to measure both glucose metabolism and synaptic density.
- Results indicated that while both synaptic density and glucose consumption were reduced in patients, the reduction in glucose uptake was greater than the decline in synaptic density, suggesting other factors contribute to hypometabolism in Lewy body disorders.
Background: The average human lifespan has increased dramatically over the past century. However, molecular and physiological alterations of the healthy brain during aging remain incompletely understood. Generalized synaptic restructuring may contribute to healthy aging and the reduced metabolism observed in the aged brain.
View Article and Find Full Text PDFBackground: Patients with Parkinson's disease (PD) often develop dementia, but the underlying substrate is incompletely understood. Generalized synaptic degeneration may contribute to dysfunction and cognitive decline in Lewy body dementias, but in vivo evidence is lacking.
Objective: The objective of this study was to assess the density of synapses in non-demented PD (nPD) subjects (N = 21), patients with PD-dementia or Dementia with Lewy bodies (DLB) (N = 13), and age-matched healthy controls (N = 15).
Background & Aims: Obeticholic acid (OCA) is an agonist of the nuclear bile acid receptor farnesoid X receptor, which regulates hepatic bile acid metabolism. We tested whether OCA treatment would influence hepatic transport of conjugated bile acids in patients with primary biliary cholangitis (PBC) who responded inadequately to treatment with ursodeoxycholic acid (UDCA).
Methods: Eight UDCA-treated patients with PBC with alkaline phosphatase ≥1.
Purpose: Loss of neuronal synapse function is associated with a number of brain disorders. The [C]UCB-J positron emission tomography (PET) tracer allows for in vivo examination of synaptic density, as it binds to synaptic vesicle glycoprotein 2A (SV2A) expressed in presynaptic terminals. Here, we characterise [C]UCB-J imaging in Göttingen minipigs.
View Article and Find Full Text PDFIntroduction: [N-methyl-C]cholylsarcosine ([C]CSar) is a tracer for imaging and quantitative assessment of intrahepatic cholestatic liver diseases and drug-induced cholestasis by positron emission tomography (PET). The purpose of this study is to determine whole-body biodistribution and dosimetry of [C]CSar in healthy humans. The results are compared with findings in a patient with primary sclerosing cholangitis (PSC) and a patient with primary biliary cholangitis (PBC) as well as with preclinical findings in pigs.
View Article and Find Full Text PDFUnlabelled: During cholestasis, accumulation of conjugated bile acids may occur in the liver and lead to hepatocellular damage. Inspired by our recent development of N-(11)C-methyl-glycocholic acid-that is, (11)C-cholylsarcosine-a tracer for PET of the endogenous glycine conjugate of cholic acid, we report here a radiosynthesis of N-(11)C-methyl-taurine-conjugated bile acids and biodistribution studies in pigs by PET/CT.
Methods: A radiosynthesis of N-(11)C-methyl-taurine-conjugated bile acids was developed and used to prepare N-(11)C-methyl-taurine conjugates derived from cholic, chenodeoxycholic, deoxycholic, ursodeoxycholic, and lithocholic acid.