Publications by authors named "Anna Chechenina"
Viruses compete with each other for limited cellular resources, and some deliver defence mechanisms that protect the host from competing genetic parasites. The phage antirestriction induced system (PARIS) is a defence system, often encoded in viral genomes, that is composed of a 55 kDa ABC ATPase (AriA) and a 35 kDa TOPRIM nuclease (AriB). However, the mechanism by which AriA and AriB function in phage defence is unknown.
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- Viruses compete for cellular resources, and some produce defense systems like PARIS, which consists of two proteins: AriA (an ATPase) and AriB (a nuclease).
- The study reveals that AriA and AriB form a large immune complex, where AriA shapes a scaffold for AriB, enabling it to detect and respond to foreign proteins.
- Phage T5 can evade this defense by using a tRNA variant that avoids cleavage by PARIS, illustrating a co-evolutionary struggle between viruses and host defenses.