Publications by authors named "Anna Calvet"
Article Synopsis
- * Research suggests that dendritic cell (DC) vaccines can trigger a beneficial type I interferon response, but preclinical trials show these vaccines don't work well in T cell-depleted environments.
- * Combining DC vaccines with PD-L1 blockade can effectively reduce tumor growth by targeting immunosuppressive macrophages, suggesting a need for comprehensive strategies in treating T cell-depleted tumors.
Although beta-amyloid (Aβ) and phosphorylated tau remain the preferred targets for disease-modifying treatments (DMT) against Alzheimer's disease (AD), part of the pathophysiological mechanisms of cognitive impairment are related to neuroinflammation and oxidative stress. In mild cognitive impairment (MCI), a prodromal stage of AD and other neurodegenerative conditions, the joint appearance of inflammation, oxidative stress, and metabolic alterations are the common pathways of neurotoxicity and neurodegeneration. The standardized extract of Ginkgo biloba EGb 761 interferes with the pathogenic mechanisms involved in both the development of cognitive impairment due to AD and that of vascular origin.
View Article and Find Full Text PDFMortality Risk Factors for Individuals Experiencing Homelessness in Catalonia (Spain): A 10-Year Retrospective Cohort Study.
Int J Environ Res Public Health
February 2021
Article Synopsis
- * A total of 475 homeless individuals were analyzed, with 60 deaths recorded, and the average age at death was found to be 49.1 years, much lower than the general population.
- * Key mortality risk factors included being Spanish-born, type 2 diabetes, alcohol use disorder, and infectious diseases, with Spanish-born individuals exhibiting higher mortality risk despite having better control over chronic diseases.
Background: Sublingual immunotherapy (SLIT) has been deployed in humans and dogs; to the best of the authors' knowledge, there are no published studies about the use of SLIT in cats.
Objectives: Evaluate the clinical efficacy of SLIT in atopic cats sensitized to dust and storage mites, assessing immunological changes associated with SLIT treatment.
Animals: Twenty-two client-owned cats with clinical signs compatible with feline atopic dermatitis (fAD) and serum allergen-specific immunoglobulin (Ig)E against house dust and storage mites.
Background: The COVID-19 pandemic has brought great disruption to health systems worldwide. This affected ongoing clinical research, particularly among those most vulnerable to the pandemic, like dementia patients. Fundació ACE is a research center and memory clinic based in Barcelona, Spain, one of the hardest-hit countries.
View Article and Find Full Text PDF