Publications by authors named "Anna Cadenar"
Background And Objective: Radical cystectomy (RC) is the standard treatment for muscle-invasive bladder cancer (MIBC). It is highly invasive and associated with perioperative risks, while bladder-preserving trimodality therapy (TMT) offers a less invasive alternative with preferable quality of life for selected patients. We aimed to compare oncological outcomes of TMT and RC in MIBC patients, and evaluate TMT-specific outcomes.
View Article and Find Full Text PDFBackground And Objective: While active surveillance (AS) is an alternative to surgical interventions in patients with small renal masses (SRMs), evidence regarding its oncological efficacy is still debated. We aimed to evaluate oncological outcomes for patients with SRMs who underwent AS in comparison to surgical interventions.
Methods: In April 2024, PubMed, Scopus, and Web of Science were queried for comparative studies evaluating AS in patients with SRMs (PROSPERO: CRD42024530299).
Background: Over the past decade, the range of surgical options to benign prostatic obstruction (BPO) has expanded significantly with the advent of minimally invasive surgical therapies (MISTs). Nevertheless, the available evidence in the field is heterogeneous. Efficacy and safety thresholds are yet to be determined.
View Article and Find Full Text PDFBackground And Objective: Although prostate magnetic resonance imaging (MRI) is increasingly used to diagnose and stage prostate cancer (PCa), the biologic and clinical significance of MRI visibility of the disease is unclear. Our aim was to examine the existing knowledge regarding the molecular correlates of MRI visibility of PCa.
Methods: The PubMed, Scopus, and Web of Science databases were queried through November 2023.
Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with a high recurrence rate after surgical therapy with curative intent. Adjuvant radiotherapy (RT) and mitotane therapy have been proposed as options following the adrenalectomy. However, the efficacy of adjuvant RT or mitotane therapy remains controversial.
View Article and Find Full Text PDFArticle Synopsis
- Radical nephroureterectomy (RNU) is the main treatment for high-risk upper tract urothelial cancer (UTUC), but the best technique for reducing intravesical recurrence (IVR) remains uncertain.
- A systematic review of 31 studies found that early ligation of the ureter and intravesical bladder cuff removal significantly reduce IVR rates, while laparoscopic RNU is associated with higher rates of IVR compared to open RNU.
- The study suggests that open RNU with early ureter ligation and intravesical cuff removal may provide better outcomes, but further research is needed to determine the best surgical approach, particularly with post-operative chemotherapy.
Article Synopsis
- The study investigates how well different eGFR formulas correlate with actual creatinine clearance (CrCI) measurements in patients with muscle-invasive bladder cancer (MIBC) undergoing cisplatin treatment.
- Conducted over a decade, the analysis found that while various eGFR calculations produced similar rates of cisplatin-ineligibility, they consistently underestimated actual kidney function as measured by CrCI.
- The research highlights that many patients previously classified as cisplatin-ineligible based on eGFR may actually be eligible when considering direct CrCI measurements, especially those with calculated eGFR values in the 40-59 mL/min range.
Background: Positron Emission Tomography-Computed Tomography using Prostate-Specific Membrane Antigen (PSMA PET/CT) is notable for its superior sensitivity and specificity in detecting recurrent PCa and is under investigation for its potential in pre-treatment staging. Despite its established efficacy in nodal and metastasis staging in trial setting, its role in primary staging awaits fuller validation due to limited evidence on oncologic outcomes. This systematic review and meta-analysis aims to appraise the diagnostic accuracy of PSMA PET/CT compared to CI for comprehensive PCa staging.
View Article and Find Full Text PDFPurpose: To compare two cohorts of patients submitted to robot-assisted partial nephrectomy (RAPN) for highly-complex renal masses (PADUA ⩾ 10) with versus without the use of 3DVMs.
Materials And Methods: We screened a prospective consecutive cohort of 152 patients submitted to RAPN with 3DVM and 1264 patients submitted to RAPN without 3DVM between 2019 and 2022. Only PADUA ⩾ 10 cases were considered eligible for analysis.
Purpose: To compare two cohorts of patients submitted to robot-assisted partial nephrectomy (RAPN) with vs without the use of three-dimensional virtual models (3DVMs).
Methods: We screened a prospective consecutive cohort of 152 patients submitted to RAPN with 3DVM and 1264 patients submitted to RAPN without 3DVM between 2019 and 2022. Propensity score matching analysis (PSMA) was applied.
Introduction: Benefits and harms of avoid the sent placement during IntraCorporeal Neobladder configuration are still debated. Our objective was to describe the step-by-step technique of Florence intracorporeal neobladder (FloRIN) configuration performed with stentless procedure focusing on perioperative and mid-term functional outcomes.
Materials And Methods: In this single institution prospective randomized 1:1 series all consecutive patients underwent Robot-Assisted Radical Cystectomy (RARC) and FloRIN reconfiguration from January 2021 to March 2021 were enrolled.
Article Synopsis
- The study aimed to evaluate the outcomes of the stentless FloRIN technique used during Robot-Assisted Radical Cystectomy (RARC) for bladder reconstruction, focusing on perioperative and mid-term results.
- A total of 63 patients participated, with half receiving the stentless procedure; results showed shorter operation times and hospital stays for those without stents, while complications were similar between both groups.
- The findings suggest that the stentless FloRIN technique is a safe and effective option for bladder reconstruction, demonstrating comparable functional outcomes regarding kidney health over a six-month follow-up.
Background: The role of redo partial nephrectomy (PN) for recurrent renal cell carcinoma (RCC) is still overlooked.
Objective: To report our experience of salvage PN for local recurrence after previous nephron-sparing surgery (NSS).
Design Setting And Participants: We prospectively gathered data from patients treated with robotic redo PN for locally recurrent RCC after previous NSS from January 2017 to January 2023.
Introduction: The aim of the study was to investigate clinical and surgical factors associated with early catheter replacement in patients treated with Holmium Laser Enucleation of the Prostate (HoLEP).
Materials And Methods: Data of patients treated with HoLEP at our Institution by a single surgeon from March 2017 to January 2021 were collected. Preoperative variables, including non-invasive uroflowmetry and abdominal ultrasonography (US), were recorded.
Introduction: Lymph node (LN) involvement is a crucial determinant of prognosis for patients with bladder cancer, and an accurate staging is of utmost importance to better identify timely and appropriate therapeutic strategies. To improve the accuracy of LN detection, as an alternative to traditional methods such as CT or MRI, 18F-FDG PET/CT has been increasingly used. 18F-FDG PET/CT is also used in post-treatment restaging after neoadjuvant chemotherapy.
View Article and Find Full Text PDFRe: Xuesong Li, Weifeng Xu, Shubo Fan, et al. Robot-assisted Partial Nephrectomy with the Newly Developed KangDuo Surgical Robot Versus the da Vinci Si Surgical System: A Double-center Prospective Randomized Controlled Noninferiority Trial. Eur Urol Focus 2023:9:133-40.
Eur Urol Focus
September 2023
Introduction: We assessed the efficacy and safety of holmium laser enucleation of the prostate (HoLEP) in patients with high comorbidity burden.
Materials And Methods: Data from patients treated with HoLEP at our academic referral center from March 2017 to January 2021 were prospectively collected. Patients were divided according to their CCI (Charlson Comorbidity Index).
Purpose: The present study sought to provide reproducible and patient-oriented metrics to assess the rate of "successful" outcomes (Trifecta) following holmium laser enucleation of the prostate (HoLEP). Clinical and surgical predictors of failure to achieve Trifecta were investigated.
Materials And Methods: We queried our prospectively collected database of all patients treated with HoLEP between March 2017 and January 2021.
Article Synopsis
- Recent research has introduced new prognostic factors for oral squamous cell carcinoma (OSCC), with tumor volume (TV) being a key focus due to its relevance in clinical practice with CT imaging.
- A study involving 140 patients who had primary surgery for OSCC evaluated the correlation between these factors and survival outcomes using statistical methods.
- Findings indicated a 5-year overall survival rate of 73.6%, with lymph-node status, relapse, and ASA classification identified as significant factors influencing disease-specific survival, while tumor volume correlated with higher rates of relapse.
Introduction: The clinical management of pT3a pathologic-upstaged renal cell carcinoma (RCC) patients is actually controversial. Aim of this study was i) to assess the impact of pT3a upstaging on oncologic outcomes after robot-assisted partial nephrectomy (RAPN) for cT1-T2 RCC; ii) to explore clinical and surgical predictors of pT3a upstaging; iii) to evaluate the differential impact of perinephric fat invasion (PFI) or sinus fat invasion (SFI) on survival outcomes after RAPN in case of upstaged pT3a RCC.
Materials And Methods: Clinical and surgical data from consecutive RCCs treated with RAPN in a single referral centre between January 2017 and June 2021 were prospectively collected and retrospectively reviewed.