Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III.

Introduction: The fractional exhaled nitric oxide (F NO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use F NO as a reliable biomarker, it is important to investigate factors that influence F NO in healthy individuals. Men have higher levels of F NO than women, but it is unclear whether determinants of F NO differ by sex.

Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren.

Background: The biological mechanisms involved in inflammatory response to air pollution are not clearly understood.

Objective: In this study we assessed the association of short-term air pollutant exposure with inflammatory markers and lung function.

Methods: We studied a cohort of 158 asthmatic and 50 nonasthmatic school-age children, followed an average of 22 weeks.

Increased net water loss by oral compared to nasal expiration in healthy subjects.

Aim Of The Study: To compare the difference in respiratory water loss during expiration through the nose and through the mouth, in healthy subjects.

Methods: The study included 19 healthy, non-smoking volunteers without any present history of non-infectious rhinitis, presenting with symptoms of rhinitis, asthma or previous nasal surgery. Nasal and oral expiratory breath condensates were collected using a breath condenser during tidal respiration at indoor resting conditions.