Diffuse Melanosis Cutis as the First Sign of Recurrence of Low-Risk Melanoma: Case Report and Systematic Review.

Introduction: Diffuse Melanosis Cutis (DMC) is a rare and late complication of metastatic malignant melanoma (MM) characterized by progressive pigmentation of skin and sometimes mucous membranes. The distinctive feature is the widespread and progressive deposition of melanin precursors in the dermis.

Objectives: The purpose of this review is to define the clinical and demographic features of DMC and to promote a deeper insight into the clinical manifestation, histological findings, and pathophysiology behind DMC.

Erosive pustular dermatosis of the scalp and multiple sclerosis: just a coincidence?

We report the case of a 23-year-old woman with an erythematous, crusted patch of the scalp, lacking pustular lesions, with partial hair loss, developed after mechanical scalp trauma. Histopathological examination showed a dermal infiltrate, predominantly peri-adnexal and peri-vascular, rich in plasma cells and lymphocytes, but lacking neutrophils, possibly as a consequence of the time elapsed since the onset of the skin disease. Reduction of functional hair follicles was evidenced.

Sensitive scalp: An epidemiologic study in patients with hair loss.

Sensitive scalp is a common condition defined by the presence of erythema and/or subjective symptoms as pain, pricking, burning, pruritus of the scalp elicited by triggering factors. Trichodynia is a term that describes a sensation of pain or burning of the scalp and was assumed to be part of sensitive scalp. Main goal of the study was to establish the prevalence of sensitive scalp in patients with trichological disorders.

Alexithymia, dissociation, and trauma in patients with chronic skin conditions.

Background: There is considerable literature concerning psychological distress and dermatological diseases. Recent studies highlight the role of emotion dysregulation in several skin diseases. Our study sought to explore emotion regulation in patients with chronic skin conditions and the frequency of traumatic experiences they had encountered.

How do disease perception, treatment features, and dermatologist-patient relationship impact on patients assuming topical treatment? An Italian survey.

Background: Psoriasis largely affects daily activities and social interactions and has a strong impact on patients' quality of life. Psoriatic patients have different attitudes toward their condition. Topical medications are essential for the treatment of psoriasis, but the majority of patients do not adhere to these therapies.

Ocular allergies: a psychodynamic approach.

Purpose Of Review: This work outlines a psychodynamic approach to ocular allergies, picking up the emotional issues related to the topic of eye out of the psychodynamic and psychosomatic literature and connecting them to a strategy of multidisciplinary treatment based on a therapeutic network that meets the unconscious patient's distresses, particularly those relating to the anxiety of abandonment, to the emotional nonmirroring and to the aspects of envy.

Recent Findings: More specifically is considered a modern psychodynamic approach able to link together the particular depth of pathology (in terms of its physiological changes) with the analogous depth of conflict and its psychological defences and able to intervene through a medical-psychological network according to the systemic criteria of the eco-bio-psychology.

Summary: The psychodynamic research on ocular allergy is currently poor and methodologically reductive.

Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma.

Mutations in the CDKN2A gene underlie melanoma susceptibility in as many as 50% of melanoma kindreds in selected populations, and several CDKN2A founder mutations have been described. Inherited mutations in CDKN2A have been found to be associated with other, non-melanoma cancers including pancreatic cancer (PC) and neural system tumors (NST). Here we report a novel germline mutation in exon 1 of the CDKN2A gene, E27X, which we first detected in melanoma patients living in or originally from a small geographic area bordering Liguria in north-western Italy.