The precise spatiotemporal expression of the hematopoietic ETS transcription factor PU.1, a key determinant of hematopoietic cell fates, is tightly regulated at the chromatin level. However, how chromatin signatures are linked to this dynamic expression pattern across different blood cell lineages remains uncharacterized.
View Article and Find Full Text PDFThe ETS transcription factor PU.1 plays an essential role in blood cell development. Its precise expression pattern is governed by cis-regulatory elements (CRE) acting at the chromatin level.
View Article and Find Full Text PDFThe precise spatio-temporal expression of the hematopoietic ETS transcription factor that determines the hematopoietic cell fates is tightly regulated at the chromatin level. However, it remains elusive as to how chromatin signatures are linked to this dynamic expression pattern across blood cell lineages. Here we performed an unbiased and in-depth analysis of the relationship between human expression, the presence of trans-acting factors, and 3D architecture at various cis-regulatory elements (CRE) proximal to the locus.
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