Body composition and concentrations of leptin, neuropeptide Y, beta-endorphin, growth hormone, insulin-like growth factor-I and insulin at menarche in girls with constitutional delay of puberty.

Aim: Constitutional delay of puberty (CDP), a rare condition among girls, manifests as retarded sexual maturity past the 13th year of life. The clinical and endocrinological aspects of this interesting problem appear to have escaped attention in the literature. The purpose of the present study was to compare body composition and concentrations of leptin, neuropeptide Y (NPY), beta-endorphin, growth hormone (GH), insulin growth factor-I (IGF-I) and insulin at menarche in CDP girls and girls with normal pubertal development (NP).

Body composition, dehydroepiandrosterone sulfate and leptin concentrations in girls approaching menarche.

Unlabelled: There is strong evidence that the initiation of adrenarche and gonadarche during puberty in girls depends on body mass in general and body fat in particular. The aim of this study was to analyze changes in body composition, i.e.

Sex features at menarche in relation to gonadotropin, estradiol and sex hormone-binding globulin concentrations in girls with constitutional delay of puberty. Preliminary report.

Objective: Constitutional delay of puberty (CDP) is the absence of secondary sexual features in otherwise healthy girls past the 13th year of life. The aim of the present work was to follow the development of estrogen-dependent sexual features, determine the concentrations of gonadotropins, estradiol and sex hormone-binding globulin (SHBG) in girls with CDP at menarche and compare the findings with normal controls.

Methods: We enrolled 11 girls with CDP and 40 controls.

[Germinal cell tumors in young and adolescent girls].

Objective: Germ cell tumours are the most common ovarian tumours in childhood and adolescence. This diverse group of tumours derives from germ cells.

Design: The aim of this work is presentation of germ cell tumours in the material from our clinic with characteristic clinical features, the scope of operation and effects of many years of observation.

[Granulosa cell tumor in different periods of women's life].

Unlabelled: Ovarian granulosa cell tumor is uncommon malignancies. By virtue of histopathological examination we distinguish two subtype of GCT: adult type granulosa cell tumor typically in older women and juvenile granulosa cell tumor recognized primarily in children and young adults. GCTs behave unpredictably.

Growth hormone, IGF-1, insulin, SHBG, and estradiol levels in girls before menarche.

The timing of pubertal changes depends on the concerted function of the hypothalamic - pituitary - ovarian and other endocrine systems. The somatotropin system and insulin play important roles during the growth and maturation of girls. Our clinical observations have enabled us to determine and implement criteria that split the pre-menarcheal period into three phases with distinct features associated with rising levels of estrogens (pre-estrogenization, onset of estrogenization and full estrogenization).

[Leptin levels during estrogenization phases in pubertal girls].

Objective: We searched for associations between leptin levels, basic body composition, primary, secondary and tertiary sex features during pre-menarche without signs of estrogenization, estrogenic crisis and full estrogenization.

Material And Methods: The study group consisted of 45 healthy girls over the age of 8 years. Height, body mass, BMI, basic body composition and plasma concentration of leptin were determined every three months.

[Biophysical parameters of early puberty in girls].

Objective: The appearance of breast development in girls characterizes an early period of puberty. Ultrasonographic examinations of the uterus and ovaries make possible the estimation of first pubertal changes in sexual organs.

Design: The aim of this work was to study the clinical and ultrasonographical features of early puberty in girls.

[Congenital agenesis of vagina and cervix].

A case of vaginal and cervical agenesis was presented. The mode of therapeutic procedure consisting of several stages was shown. Menstruation to abdominal cavity was stopped, using pharmacological agent.