This research focuses on finding non-invasive markers to predict the recurrence of autoimmune liver diseases in children, which traditionally require invasive liver biopsies for monitoring.
The study analyzed blood serum from 80 children with autoimmune liver conditions, observing the relationship between monocyte subpopulations and disease activity through flow cytometry and other markers.
Results showed that specific monocyte types, particularly intermediate CD14++/CD16+ and non-classical CD14lowCD16+ monocytes, are linked to disease activity and could serve as valuable biomarkers for predicting relapses.