Quetiapine Twice Daily Versus Bedtime Dosing in the Treatment of ICU Delirium.

Although guidelines recommend twice daily (BID) dosing of quetiapine for treatment of intensive care unit (ICU) delirium in most patients, once daily dosing at bedtime (HS) is commonly prescribed to reduce daytime somnolence. No studies have evaluated differences in outcomes. To determine if twice daily vs bedtime dosing of quetiapine reduces the duration of ICU delirium.