Publications by authors named "Anna B. Semerjyan"
Patterns of alveolar macrophage activation upon attenuated and virulent African swine fever viruses in vitro.
Comp Immunol Microbiol Infect Dis
October 2020
Article Synopsis
- The study examined how two strains of African swine fever (ASF) viruses affect the activation of porcine alveolar macrophages (AM), noting differences in immune response.
- Cells infected with the virulent ASFV-Georgia2007 showed unique M1 polarization and changes in morphology, resulting in lower synthesis of certain interferons compared to those infected with the attenuated strain ASFV-BA71V.
- The findings suggest that the more virulent ASFV-Georgia2007 reduces the antiviral response of AM, indicating that the evolutionary decrease of ASFV virulence is linked to changes in host immune system regulation.
Aim: The aim of this research was to study the effect of rabbit hemorrhagic disease virus (RHDV) on the host immune response by examining the cellular composition/pathology of lymphoid organs and serum levels of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ).
Materials And Methods: Nine adult rabbits were inoculated with 1 ml of 10% infected liver homogenate, and three rabbits served as controls. The rabbit hemorrhagic disease (RHD)-induced animals were studied on 3 consecutive days post-infection.
Glomerulonephritis due to African swine fever (ASF) is well documented. However, there is absence of good understanding of mechanisms involved in the development of pathology development. This study examines glomerulonephritis in association with acute infection induced by II genotype (Georgia 2007) of ASF virus.
View Article and Find Full Text PDFThe present study describes the gross, histopathologic lesions of the heart arising in pigs infected with acute African Swine Fever (ASF) and their biochemical profile. Ten pigs were infected by intramuscular injection of ASF virus (Georgia 2007). Selected heart samples were submitted for histopathological examination and Hematoxylin-Basic Fuchsin-Picric Acid (HBFP) staining.
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