Publications by authors named "Anna A Nagel"
Article Synopsis
- Ancient DNA (aDNA) is being used to explore evolutionary relationships and timelines of species, both alive and extinct, with a focus on the challenges presented by older samples.
- Traditional methods that use the age of samples often produce incorrect gene trees instead of accurate species trees, leading to biased results.
- A new multispecies coalescent (MSC) model has been developed and tested, showing strong performance in accurately estimating divergence times and mutation rates when correctly incorporating ancient sample data.
Bayesian phylogenetic inference of HIV latent lineage ages using serial sequences.
J R Soc Interface
April 2023
Article Synopsis
- - HIV evolves quickly within individuals, but latent HIV sequences evolve slowly, allowing researchers to study when these sequences entered the latent reservoir and understand their dynamics.
- - A new Bayesian method is developed to estimate the integration times of latent HIV sequences, using biologically relevant parameters that other methods often overlook.
- - The method has been tested and shown to yield more accurate estimates for latent integration dates, which are important for correlating these times with significant events in HIV infection, demonstrated through data from four patients.