Publications by authors named "Ann-Marie Bergholm"
Toxicol Pathol
February 2018
Article Synopsis
- - The study developed a 2-stage model to explore urinary bladder cancer in male Sprague-Dawley rats by first initiating tumors with a chemical called BBN and then testing potential tumor promoters over a 26-week period.
- - Rats treated with rosiglitazone and uracil showed a significant increase in bladder tumors, with uracil being the most effective, leading to a high percentage of transitional cell carcinomas (TCCs).
- - Sodium ascorbate appeared to have a protective effect, reducing the development of bladder cell hyperplasia without promoting tumor formation, confirming the model's effectiveness in identifying tumor promoters.
