Publications by authors named "Ann Yu-Jung Shih"
Mol Cell Neurosci
August 2012
Article Synopsis
- The amyloid precursor protein (APP) is crucial in Alzheimer's disease, as it gets cleaved to form amyloid β-protein (Aβ), a key factor in forming senile plaques.
- A study using APP knock-out mice showed a significant decrease in dendritic spine density and other neuronal issues, indicating APP is important for maintaining synaptic structure and function.
- These morphological and functional deficits were more pronounced in older mice (12-15 months) than in younger ones, suggesting age-related changes tied to Alzheimer's pathology may occur independently of Aβ toxicity.
