Publications by authors named "Ann Y Shih"
As the result of a rhJNK1 HTS, the imidazo[1,2-a]quinoxaline 1 was identified as a 1.6 μM rhJNK1 inhibitor. Optimization of this compound lead to AX13587 (rhJNK1 IC50=160 nM) which was co-crystallized with JNK1 to identify key molecular interactions.
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- The amyloid precursor protein (APP) is crucial in Alzheimer's disease, as it gets cleaved to form amyloid β-protein (Aβ), a key factor in forming senile plaques.
- A study using APP knock-out mice showed a significant decrease in dendritic spine density and other neuronal issues, indicating APP is important for maintaining synaptic structure and function.
- These morphological and functional deficits were more pronounced in older mice (12-15 months) than in younger ones, suggesting age-related changes tied to Alzheimer's pathology may occur independently of Aβ toxicity.