Publications by authors named "Ann Walkush"
Background: Chimeric antigen receptor (CAR) T cell therapy is an effective salvage therapy for pediatric relapsed B-cell acute lymphoblastic leukemia (B-ALL), yet is challenged by high rates of post-CAR relapse. Literature describing specific relapse patterns and extramedullary (EM) sites of involvement in the post-CAR setting remains limited, and a clinical standard for post-CAR disease surveillance has yet to be established. We highlight the importance of integrating peripheral blood minimal residual disease (MRD) testing and radiologic imaging into surveillance strategies, to effectively characterize and capture post-CAR relapse.
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- Classic Hodgkin lymphoma (CHL) can occasionally present with other lymphoma types that have different characteristics, complicating diagnosis and treatment due to their similarities.
- In a study of 509 CHL patients, researchers found 6 cases where patients had different lymphoma diagnoses, revealing shared genetic mutations that indicate a clonal relationship among the different types of lymphoma.
- The study suggests that detailed genetic profiling could help manage patients with recurring or treatment-resistant cases, emphasizing the interconnectedness of CHL and other lymphomas, and highlighting important genetic factors that could affect treatment choices.