Digital therapeutic improves visual acuity and encourages high adherence in amblyopic children in open-label pilot study.

Background: The effectiveness of amblyopia therapy can be limited by poor adherence. Dichoptic therapies are a new approach, but recent trials have demonstrated difficulty maintaining high adherence over extended periods of at-home treatment. We evaluated the efficacy and adherence of Luminopia One-a dichoptic treatment that applies therapeutic modifications to streaming content chosen by the patient.

Rate of ocular trauma in children operated on for unilateral cataract in infancy-data from the Infant Aphakia Treatment Study.

To determine whether the fellow eye of children who have undergone unilateral cataract extraction in the first year of life are at increased risk of injury and vision loss, the 10.5-year data on 109 of 114 children enrolled in the Infant Aphakia Treatment Study were examined. Based on this limited data, it was estimated that the fellow eye is at greater risk of injury than the operated eye.

Improved adherence and treatment outcomes with an engaging, personalized digital therapeutic in amblyopia.

Given the prevalence of poor adherence to therapy and the biases of self-reporting across healthcare, we hypothesized that an engaging, personalized therapy may improve adherence and treatment outcomes in the home. We tested this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for which available treatments are limited by low adherence. We designed a novel digital therapeutic that modifies patient-selected cinematic content in real-time into therapeutic visual input, while objectively monitoring adherence.

The Relationship of Age and Other Baseline Factors to Outcome of Initial Surgery for Intermittent Exotropia.

Purpose: To determine whether age at surgery is associated with surgical outcome of intermittent exotropia (IXT) at 3 years.

Design: Secondary analysis of pooled data from a randomized trial.

Methods: A total of 197 children 3 to <11 years of age with basic-type IXT of 15-40 prism diopters (Δ) were randomly assigned to 1 of 2 surgical procedures for treatment of intermittent exotropia.

Stereopsis results at 4.5 years of age in the infant aphakia treatment study.

Purpose: To determine whether stereopsis of infants treated for monocular cataracts varies with the type of optical correction used.

Design: Randomized prospective clinical trial.

Methods: The Infant Aphakia Treatment Study randomized 114 patients with unilateral cataracts at age 1-7 months to either primary intraocular lens (IOL) or contact lens correction.

Blepharophimosis syndrome with absent tear production.

The purpose of this report was to present a case of congenital alacrima in a patient with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). A 9-month-old boy presented with characteristic clinical findings of BPES confirmed by genetic testing. On further history taking and evaluation, the patient was noted to have no tear production, despite clinically present palpebral lobes of the lacrimal glands.

Giant orbital cysts after strabismus surgery.

Purpose: To describe a rarely reported complication of strabismus surgery.

Design: Observational case series.

Methods: A review of four eyes in three patients with orbital cysts following strabismus surgery.

Experience with the baerveldt glaucoma implant in the management of pediatric glaucoma.

Purpose: To report the clinical outcome in 48 eyes of 48 children who received a Baerveldt glaucoma implant (BGI) for the management of pediatric glaucoma.

Design: Retrospective, noncomparative case series.

Methods: The medical records of all patients with pediatric glaucoma who underwent a BGI at two tertiary care referral centers in Los Angeles between 1990 and 1999 were reviewed.

Retinopathy of prematurity.

Retinopathy of prematurity (ROP) is a relatively new condition. Only in the last 60 years have children survived who were born prematurely enough to have a significantly immature retinal vasculature. This article describes the classification and physiology of ROP, the interventions now available, and possible future therapies.