Publications by authors named "Ann Georgi"
Article Synopsis
- The anaphase promoting complex (APC) plays a key role in protein degradation as cells transition from mitosis to S-phase, with its activity regulated by phosphorylation.
- Various antimitotic drugs (taxol, nocodazole, vincristine, monastrol) were used to arrest HeLa S3 cells in prometaphase, revealing differences in phosphorylation patterns across the APC despite similar arrest states.
- The study highlights that the phosphorylation status of the APC is dynamic during drug-induced mitotic arrest, which may have implications for the effectiveness of antimitotic drugs in cancer treatment.
Background: Regulation of the major transitions in the cell cycle, such as G1/S, G2/M, and metaphase to anaphase, are increasingly well understood. However, we have a poor understanding of the timing of events within each phase of the cell cycle, such as S phase or early mitosis. Two extreme models of regulation are possible.
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