Publications by authors named "Ankur Vashi"
Mechanistic Insights into Tau Protein-Mediated Regulation of Oxidative Stress.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
October 2024
Article Synopsis
- Abnormal tau protein behavior, including hyperphosphorylation and aggregation, is a major feature of tauopathies like Alzheimer's disease, leading to neurodegeneration.
- The interaction between oxidative stress and tau pathology is complex, with both factors contributing to neuronal damage through impaired microtubule stability and transport.
- Further research into oxidative stress sources, such as microglial cells, could improve our understanding of tauopathies and aid in developing new treatment strategies.
Secondary structure refers to highly regular local sub-structures formed by the polypeptide backbone through hydrogen bonding. The two main types of secondary structures are α-helices and β-strands (which can form β-sheets). The development of a robust circular dichroism (CD) method for structural analysis of biomolecules requires careful consideration of several key factors.
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