Members of the Regulatory Lymphocyte Club in Common Variable Immunodeficiency.

The role of CD4 T regulatory cells is well established in peripheral tolerance and the pathogenesis of the murine model and human autoimmune diseases. CD4 T regulatory cells (CD4 Tregs) have been investigated in common variable immunodeficiency (CVID). Recently, additional members have been added to the club of regulatory lymphocytes.

Surgical challenges associated with the morphology of the spinal accessory nerve in the posterior cervical triangle: functional or structural?

Object: The spinal accessory nerve (SAN) has been reported to have a distinctly coiled appearance in its course through the posterior cervical triangle of the neck. As this is unusual compared with other peripheral nerves including the cranial nerves, the present histological analysis was performed to further elucidate the reason for this anatomy with potential application in nerve injury and repair.

Methods: Ten adult cadavers underwent dissection of the neck.

Clinical anatomy of the mastoid and occipital emissary veins in a large series.

Introduction: Detailed descriptions of the mastoid emissary veins (MEVs) and the foramina through which they travel are lacking in the literature. Therefore, the aim of our study was to explore and delineate the morphology, topography and morphometry of the MEV, mastoid foramen (MF) and occipital foramen (OF). One hundred cadaver heads and 100 dried human skulls were grossly examined

Results: The MF and OF varied from being absent to having as many as four small openings, each transmitting an emissary vein.

An anatomic investigation of the serratus posterior superior and serratus posterior inferior muscles.

In classical anatomy textbooks the serratus posterior superior muscle was said to elevate the superior four ribs, thus increasing the AP diameter of the thorax and raising the sternum. However, electromyographic and other studies do not support its role in respiration. In order to help resolve this controversy and provide some insight into their possible functionality, the present study aimed at examining the morphology, topography and morphometry of serratus posterior superior and inferior muscles in both normal specimens and those derived from patients with a history of chronic obstructive pulmonary disorder (COPD).

Death of memory T-cell subsets in humans: changes during aging.

Aging is characterized by a progressive decline in various T-cell functions that are associated with a deficiency of naive and central memory T-cell subsets and the accumulation of oligoclonal effector memory T-cell subsets. In this article, we briefly review different pathways of death signaling and alterations in apoptotic signaling pathways in order to understand changes in various T cells in human aging.

Cisterna chyli: a detailed anatomic investigation.

With recent laparoscopic advancements in retroperitoneal and thoracic surgical procedures, familiarity with major lymphatic structures, such as including the cisterna chyli (CC) and thoracic duct (TD), has proven beneficial in avoiding misdiagnosis and iatrogenic intraoperative injury. In this light, the aim of our study was to explore and delineate the topography of the CC, classify the different patterns of lymphatic tributaries, and categorize its varying location with respect to the vertebral bodies. The anatomy of the CC was examined in 120 adult human cadavers.

An unusual innervation of pectoralis minor and major muscles from a branch of the intercostobrachial nerve.

Variations of the branching pattern of the intercostobrachial nerve have been known to complicate dissection during mastectomy and other procedures involving the axilla. We present a unilateral case of a 73-year-old Caucasian female, in which the intercostobrachial nerve gives rise to an additional medial pectoral branch, which partially innervates the pectoralis minor muscle, as well as the abdominal head of pectoralis major muscle. Clinical consequences of such a variation may include motor losses, in addition to the commonly reported sensory losses, resulting from accidental or intentional dissection of the intercostobranchial nerve.

Anatomical and surgical considerations of the sacrotuberous ligament and its relevance in pudendal nerve entrapment syndrome.

In view of the paucity of literature, this study was undertaken to reappraise the gross anatomy of the sacrotuberous ligament (STL), with the objective of providing an accurate anatomical basis for clinical conditions involving the STL. We studied the gross anatomy of the STL in 50 formalin fixed cadavers (100 sides) during the period of 2004-2005. All specimens exhibited an STL with a ligamentous part and (87%) of specimens exhibited a membranous (falciform) segment, which extended towards the ischioanal fossa.