Publications by authors named "Ankita Walvekar"
Abdominal aortic aneurysm (AAA) is associated with the loss of vascular smooth muscle cells (SMCs) within the vessel wall. Direct delivery of therapeutic cells is challenging due to impaired mechanical integrity of the vessel wall. We hypothesized that porous collagen scaffolds can be an effective vehicle for the delivery of human-derived SMCs to the site of AAA.
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- Previous research showed that Stempeucel®-1, a type of bone marrow-derived stem cell, effectively treated critical limb ischemia (CLI) in patients with Buerger's disease, and a second generation (Stempeucel®-1A) has been developed to ensure continuity in treatment.
- *Both versions of Stempeucel® underwent analysis to compare their gene and protein expressions, secreted growth factors, and immunomodulatory activities through various lab tests and an animal model.
- *Results indicated that both stem cell products had similar angiogenic and immune regulatory properties, and when tested in mice, both versions significantly repaired tissue damage from ischemia, improving function and longevity in the affected limbs.
Background: Mesenchymal stromal cells (MSCs) have emerged as a more beneficial alternative to conventional therapy and may offer a potential cure for unmet medical needs. MSCs are known to possess strong immunomodulatory and anti-inflammatory properties. Moreover, they promote angiogenesis and tissue regeneration through the secretion of trophic factors.
View Article and Find Full Text PDFHedgehog (Hh) is a secreted morphogen that elicits differentiation and patterning in developing tissues. Multiple proposed mechanisms to regulate Hh dispersion includes lipoprotein particles and exosomes. Here we report that vertebrate Sonic Hedgehog (Shh) is secreted on two types of extracellular-vesicles/exosomes, from human cell lines and primary chick notochord cells.
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