Bismuth niobate/g-CN heterojunction for maximised visible light photocatalytic removal of Bisphenol A.

The occurrence of xenobiotic pollutants in the aquatic environment troubling the present and future generation. Persistent Organic Pollutants (POPs) is one such class of xenobiotic that was dominant in that category. In the present paper, a competent visible light driven heterojunction photocatalyst combining Bismuth niobate and g-CN was developed for the effective removal of Bisphenol A (BPA), a notable POP.

Discovery, SAR and mechanistic studies of quinazolinone-based acetamide derivatives in experimental visceral leishmaniasis.

Towards identification of novel therapeutic candidates, a series of quinazolinone-based acetamide derivatives were synthesized and assessed for their anti-leishmanial efficacy. Amongst synthesized derivatives, compounds F12, F27 and F30 demonstrated remarkable activity towards intracellular L. donovani amastigotes in vitro, with IC values of 5.

Quinolinyl β-enaminone derivatives exhibit leishmanicidal activity against Leishmania donovani by impairing the mitochondrial electron transport chain complex and inducing ROS-mediated programmed cell death.

Objectives: Previously, a series of side chain-modified quinolinyl β-enaminones was identified to possess significant activity against chloroquine-sensitive or -resistant Plasmodium falciparum and Brugia malayi microfilariae. The present study evaluates in vitro and in vivo activity of the series against Leishmania donovani and reports their mode of action.

Methods: The in vitro activity of 15 quinolinyl β-enaminone derivatives against Leishmania promastigotes and amastigotes was assessed by luciferase assay.

Discovery of 2,3-dihydro-1-pyrrolo[3,4-]quinolin-1-one derivatives as possible antileishmanial agents.

A series of uniquely functionalized 2,3,-dihydro-1-pyyrolo[3,4-]quinolin-1-one derivatives were synthesized in one to two steps by utilizing a post-Ugi modification strategy and were evaluated for antileishmanial efficacy against visceral leishmaniasis (VL). Among the library compounds, compound 5m exhibited potential antileishmanial activity (CC = 65.11 μM, SI = 7.

Heterojunction formation between AgNbO and CoO for full solar light utilization with improved charge-carrier separation.

In the present study, the charge-carrier recombination of visible light active perovskite silver niobate (AgNbO) was reduced by forming heterojunction with CoO through simple impregnation and calcination route. The loading percentage of CoO was varied as 2, 5, and 10 wt.%.

A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys.

Data science has been an invaluable part of the COVID-19 pandemic response with multiple applications, ranging from tracking viral evolution to understanding the vaccine effectiveness. Asymptomatic breakthrough infections have been a major problem in assessing vaccine effectiveness in populations globally. Serological discrimination of vaccine response from infection has so far been limited to Spike protein vaccines since whole virion vaccines generate antibodies against all the viral proteins.

Jagged-Notch-mediated divergence of immune cell crosstalk maintains the anti-inflammatory response in visceral leishmaniasis.

Notch signaling governs crucial aspects of intercellular communication spanning antigen-presenting cells and T-cells. In this study, we investigate how takes advantage of this pathway to quell host immune responses. We report induction of the Notch ligand Jagged1 in -infected bone marrow macrophages (BMMϕs) and subsequent activation of RBPJκ (also known as RBPJ) in T cells, which in turn upregulates the transcription factor GATA3.

ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine.

A dopamine receptor antagonist, Thioridazine (TDZ) is known for its cytotoxic activity against various cancers and its role in combinational chemotherapy is being actively investigated. Several molecular targets of TDZ have been studied to delineate its anticancer activities, with contrasting findings in different cancer types. Moreover, the underlying mechanism of cell death from TDZ treatment is not well defined.