Ru(II)-Catalyzed C(sp)-H Activation Annulation: Synthesis of Fluorescent Benzoisoquinolonyl Acetate/Peptides from -Arylamides and Ethyne at Room Temperature.

Benzoisoquinolones are aryl ring extended isoquinolinone derivatives, which are constituents of alkaloid natural products. This report describes the synthesis of novel benzoisoquinolone amino acid/peptide derivatives from the respective -aryl amino esters/peptides through Ru-catalyzed C(sp)-H annulation at room temperature. The -terminal amide acts as an intrinsic directing group and coordinates with the active Ru(II) catalyst for the C-H bond activation and annulation of the aryl ring to produce benzoisoqunolone derivatives.

Think before throw: waste chili stalk powder for facile scavenging of cationic dyes from water.

Chili stalk powder (CS), a non-conventional adsorbent, has been exercised for facile removal of cationic dyes from simulated and wastewater by batch technique. The prepared material has been characterized by Fourier-transform infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), Brunauer-Emmett-Teller analysis (BET), powder X-ray diffraction (powder XRD), and pH and tested best with methylene blue and crystal violet under ambient conditions. FTIR denotes the presence of carbonyl and polyphenolic groups, responsible for dye adsorption.

Early Discontinuation of Apremilast in Patients with Psoriasis and Gastrointestinal Comorbidities: Rates and Associated Risk Factors.

Introduction: Apremilast, the first oral targeted treatment for moderate to severe psoriasis, is associated with diarrhea, nausea, and vomiting, which have contributed to treatment discontinuation. This study describes early apremilast discontinuation rates in patients with psoriasis, including a cohort with gastrointestinal (GI) comorbidities, and associated characteristics.

Methods: This retrospective cohort study used IBM (now Merative™) MarketScan commercial and Medicare claims data to identify adults with psoriasis who filled their first apremilast prescription between September 1, 2014 and March 31, 2020.

Synthesis of -isoindolinonyl peptides Pd-catalyzed C(sp)-H olefination-activation and their conformational studies.

Isoindolinone is a constituent of several natural products that show a wide range of bioactivity, such as anticancer, antimicrobial, antiviral and anti-inflammatory properties. It would be interesting to explore the carbonyl group (H-bond acceptor) of isoindolinone and its structural and conformational changes. However, the synthesis of isoindolinone-comprising peptides in short steps is challenging.