Publications by authors named "Ankita P Desai"
Less than 5% of children who report penicillin allergy have clinically pertinent type 1 immunoglobulin E mediated hypersensitivity reaction by using direct oral amoxicillin challenge. Several pathways have been developed to delabel penicillin allergy by using direct oral amoxicillin challenge, mostly in the outpatient settings, but there is relative scarcity on published outcomes of these pathways, especially in the inpatient pediatric settings. This study aimed to evaluate the performance of an institutionally derived inpatient penicillin allergy screening tool.
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- HIV infection can be prevented using pre-exposure prophylaxis (PrEP), but many primary-care physicians lack knowledge and comfort in prescribing it.
- A 40-minute case-based lecture on the 2021 HIV-PrEP guidelines was integrated into medical residency training to address these issues.
- The study found significant improvement in residents' knowledge and confidence about PrEP, suggesting that training can enhance its delivery and help meet National HIV/AIDS Strategy goals.
The use of 16S rRNA sequencing in culture-negative infections has improved identification of bacterial pathogens in select scenarios, but its clinical impact requires further elucidation, especially in the pediatric population. This retrospective study aims to determine the clinical utility of 16S rRNA sequencing on the clinical management of pediatric culture-negative infections in our institution. Significant clinical utility was identified in 30 (40.
View Article and Find Full Text PDFBackground: We investigated the association of vitamin K and vitamin D with coronavirus disease 2019 (COVID-19) outcomes.
Methods: Levels of inactive vitamin K-dependent dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP; marker of vitamin K status) and 25-hydroxyvitamin D (25(OH)D; vitamin D status) were measured in plasma samples from participants with confirmed acute COVID-19 and were age- and sex-matched to healthy controls. Unadjusted odds ratios and adjusted odds ratios (AORs) with 95% CIs were computed using cumulative logistic regression.
Background: Streptococcus pneumoniae (SP) serotype distribution among nasopharyngeal (NP) carriage isolates changed significantly after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7). We evaluated the impact on NP carriage and invasive disease of SP after the introduction of the 13-valent PCV (PCV13) in March 2010.
Methods: NP swabs were collected from children 6-59 months of age in an emergency department from July 2010 to June 2013.
Background: Matrix-assisted laser desorption ionisation-time of flight mass spectrometry (MALDI-TOF MS) has been described as a rapid, accurate method for bacterial identification.
Aims: To investigate the ability of the technique, using the unamended database supplied with the system, to identify bacteria commonly isolated in cystic fibrosis (CF) patients.
Methods: Organisms commonly isolated from CF patients identified by MALDI-TOF MS were compared to conventional phenotypic and genotypic analyses.