Publications by authors named "Ankita Kushwaha"
Trans-Cervical Approach To The Thoracic Outlet Syndrome.
Indian J Otolaryngol Head Neck Surg
August 2024
Article Synopsis
- Thoracic outlet syndrome results from compression of nerves and blood vessels in the thoracic outlet, causing symptoms in the shoulder and upper limb.
- Proper diagnosis requires identifying the underlying cause through thorough clinical examinations and specific tests.
- The manuscript will cover thoracic outlet syndrome, particularly focusing on cervical ribs as a cause, including its incidence, symptoms, diagnosis, and surgical management, especially through a transcervical approach.
The SELEX (Systematic Evolution of Ligands by EXponential enrichment) method has been used successfully since 1990, but work is still required to obtain highly specific aptamers. Here, we present a novel approach called 'Competitive non-SELEX' (and termed as 'SELCOS' (Systematic Evolution of Ligands by COmpetitive Selection)) for readily obtaining aptamers that can discriminate between highly similar targets. This approach is based on the theoretical background presented here, in which under the co-presence of two similar targets, a specific binding type can be enriched more than a nonspecifically binding one during repetitive steps of partitioning with no PCR amplification between them.
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