Evidence of the Immunomodulatory Effects of Selective Serotonin Reuptake Inhibitors in Patients With Depression Through a Systematic Review.

Depression is a common illness, affecting >264 million people worldwide. According to the literature, depression patients have baseline subclinical inflammation. The immunomodulatory effects of antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are largely unclear and poorly understood.

Formulation and evaluation of mixed matrix gastro-retentive drug delivery for famotidine.

Introduction: Present investigation describes an influence of ratio of Gelucire 43/01(hydrophobic) to hydroxypropyl methylcellulose K4M (HPMC K4M) (hydrophilic) and different fillers on release of famotidine from gastro-retentive tablets using 3(2) full factorial design. Ratio of Gelucire 43/01 to HPMC K4M (X(1)) and the type of filler (X(2)) were selected as independent variables while buoyancy lag time (BLT), drug release at 1h (Q(1)), 6h (Q(6)), and the 12h (Q(12)) were selected as dependent variables.

Materials And Methods: Gastro-retentive tablets of famotidine were prepared by a solvent free melt granulation technique using Gelucire 43/01 as a hydrophobic meltable binder.