Publications by authors named "Ankie M van Cromvoirt"
Density reversal of senescent red blood cells has been known for a long time, yet the identity of the candidate ion transporter(s) causing the senescent cells to swell is still elusive. While performing fractionation of RBCs from healthy individuals in Percoll density gradient and characterization of the separated fractions, we identified a subpopulation of cells in low-density fraction (1.02% ± 0.
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- * Results showed that while gender had no impact, the age of donors significantly influenced the O_hyper parameter, indicating a correlation between RBC age and their properties.
- * The research found that younger RBCs (L-fraction) produced more oxidants yet had higher levels of reduced thiols compared to older RBCs, prompting a recommendation for age-stratified reference values in diagnosing RBC-related conditions.
Background: Subcellular localization and function of L-type calcium channels (LTCCs) play an important role in regulating contraction of cardiomyocytes. Understanding how this is affected by the disruption of transverse tubules during heart failure could lead to new insights into the disease.
Methods: Cardiomyocytes were isolated from healthy donor hearts, as well as from patients with cardiomyopathies and with left ventricular assist devices.