Serum proteomics reveals hemophagocytic lymphohistiocytosis-like phenotype in a subset of patients with multisystem inflammatory syndrome in children.

Children with Multisystem Inflammatory Syndrome in Children (MIS-C) can present with thrombocytopenia, which is a key feature of hemophagocytic lymphohistiocytosis (HLH). We hypothesized that thrombocytopenic MIS-C patients have more features of HLH. Clinical characteristics and routine laboratory parameters were collected from 228 MIS-C patients, of whom 85 (37%) were thrombocytopenic.

The introduction of allergenic foods and the development of reported wheezing and eczema in childhood: the Generation R study.

Objective: To examine whether the timing of introduction of the allergenic foods cow's milk, hen's egg, peanuts, tree nuts, soy, and gluten is associated with eczema and wheezing in children 4 years of age or younger.

Design: Population-based prospective cohort study from fetal life until young adulthood.

Setting: Rotterdam, the Netherlands, from April 2002 through January 2006.

Natural antibodies against several pneumococcal virulence proteins in children during the pre-pneumococcal-vaccine era: the generation R study.

The currently available pneumococcal vaccines do not protect against all serotypes of Streptococcus pneumoniae. A shift toward nonvaccine serotypes causing colonization and invasive disease has occurred, and studies on protein-based vaccines have been undertaken. We assessed the association between specific antibodies against pneumococcal virulence proteins and colonization and respiratory tract infections (RTIs).

The inverse correlation between Staphylococcus aureus and Streptococcus pneumoniae colonization in infants is not explained by differences in serum antibody levels in the Generation R Study.

Colonization rates of Streptococcus pneumoniae and Staphylococcus aureus are inversely correlated in infants. Several studies have searched for determinants of this negative association. We studied the association between antipneumococcal antibodies with Staphylococcus aureus colonization and the association between antistaphylococcal antibodies with pneumococcal colonization in healthy children in the pneumococcal vaccine era.

Risk factors for otitis media in children with special emphasis on the role of colonization with bacterial airway pathogens: the Generation R study.

Acute otitis media is the most frequent diagnosis in children visiting physicians' offices. Risk factors for otitis media have been widely studied. Yet, the correlation between bacterial carriage and the development of otitis media is not entirely clear.

Correlation of bacterial colonization status between mother and child: the Generation R Study.

Determinants of bacterial colonization in children have been described. In the Generation R Study, a population-based cohort study, we determined whether the colonization statuses of mothers and children are correlated. Such a correlation was observed for Staphylococcus aureus and Haemophilus influenzae.

Role of Staphylococcus aureus nasal colonization in atopic dermatitis in infants: the Generation R Study.

Objective: To study the association between Staphylococcus aureus nasal colonization and atopic dermatitis (AD) in infancy.

Design: Population-based prospective cohort study of pregnant women and their children.

Setting: This project was embedded in the Generation R Study.

Dynamics and determinants of Staphylococcus aureus carriage in infancy: the Generation R Study.

Serial nasal swabs were collected at the ages of 1.5, 6, and 14 months from 443 infants in the Generation R Study. The objective was to study the dynamics and determinants of Staphylococcus aureus nasal carriage in the first year of life.

Short communication: CD4 counts of HIV-infected pregnant women and their infected children--implications for PMTCT and treatment programmes.

A considerable proportion of pregnant women and their infected children are likely to be eligible for anti-retroviral treatment. The antenatal-postnatal divide needs to be bridged with respect to the follow-up of both HIV-infected women and their exposed infants.