Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2.

TRPM2 is a non-selective, Ca-permeable cation channel, which plays a role in cell death but also contributes to diverse immune cell functions. In addition, TRPM2 contributes to the control of body temperature and is involved in perception of non-noxious heat and thermotaxis. TRPM2 is regulated by many factors including Ca, ADPR, 2'-deoxy-ADPR, Ca-CaM, and temperature.