6q22.33 microdeletion in a family with intellectual disability, variable major anomalies, and behavioral abnormalities.

Interstitial deletions on the long arm of chromosome six have been described for several regions including 6q16, 6q22.1, and 6q21q22.1, and with variable phenotypes such as intellectual disability/developmental delay, growth retardation, major and minor facial anomalies.

Training-induced plasticity of the social brain in autism spectrum disorder.

Background: Autism spectrum disorder (ASD) is linked to social brain activity and facial affect recognition (FAR).

Aims: To examine social brain plasticity in ASD.

Method: Using FAR tests and functional magnetic resonance imaging tasks for FAR, we compared 32 individuals with ASD and 25 controls.

Targeted and genomewide NGS data disqualify mutations in MYO1A, the "DFNA48 gene", as a cause of deafness.

MYO1A is considered the gene underlying autosomal dominant nonsyndromic hearing loss DFNA48, based on six missense variants, one small in-frame insertion, and one nonsense mutation. Results from NGS targeting 66 deafness genes in 109 patients identified three families challenging this assumption: two novel nonsense (p.Tyr740* and p.

[Getting through to adolescents "online". The use of web-based programs for stress-prevention in youth].

Adolescents can be regarded as a difficult target group for health promotion efforts. Therefore, possibilities and limitations in the use of the internet for stress prevention in adolescents are explored in two empirical studies. The first study with 1988 adolescents in grades seven to nine examines to what extent the internet is used by adolescents and the importance of the internet as a contact point for the solution of problems with school, parents etc.