Publications by authors named "Ankang Ying"
Article Synopsis
- - Eye drops are being developed as a promising non-invasive treatment for diseases affecting the back of the eye, but their effectiveness is challenged by various eye barriers.
- - Researchers propose using a single molecule nanomedicine called sulfonated azocalix[4]arene (SAC4A) to improve drug delivery, highlighted by its small size, negative charge, and ability to release drugs in low-oxygen conditions.
- - A study demonstrated that SAC4A could effectively deliver the drug sunitinib to treat wet age-related macular degeneration (wAMD), increasing the amount of drug reaching the targeted eye tissue significantly and enhancing its treatment effects.
Antibody-Calixarene Drug Conjugate: A General Drug Delivery Platform for Tumor-Targeted Therapy.
ACS Appl Mater Interfaces
August 2024
Antibody-drug conjugates (ADCs), which combine the precise targeting capabilities of antibodies with the powerful cytotoxicity of small-molecule drugs, have evolved into a promising approach for tumor treatment. However, the traditional covalent coupling method requires the design of a specific linker tailored to the properties of the small-molecule drugs, which greatly limits the development of ADCs and the range of drugs that can be used. Herein, a novel type of antibody-calixarene drug conjugates (ACDCs) that function similarly to ADCs by delivering drugs to their targets using antibodies but without the requirement of covalent conjugation of the drugs with antibodies is presented.
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- The rising rates of metabolic disorders are linked to changes in diet and lifestyle, emphasizing the need for monitoring metabolic health for early detection and intervention.
- Hippuric acid (HA), a common metabolite from gut bacteria, shows promise as an indicator of metabolic health and could help in large-scale health monitoring.
- A new method using a specific chemical sensor was developed to measure HA levels in urine, highlighting that higher urinary HA concentration is associated with a lower risk of metabolic disorders, reinforcing the role of a healthy diet rich in fruits, coffee, and tea.
Article Synopsis
- Chemotherapy often has severe side effects, which can limit its effectiveness in treating cancer, necessitating methods to remove off-target drugs from the serum.
- This study developed adsorption materials by modifying MOF nanosheets with sulfonated azocalix[4]arenes, which strongly bind to the chemotherapy drug doxorubicin for improved drug removal.
- The synthesized adsorbents offer high efficiency in eliminating doxorubicin from serum, achieving up to 91% removal in just 5 minutes with low toxicity and high compatibility in physiological environments.
Nanomedicines often rely on noncovalent self-assembly and encapsulation for drug loading and delivery. However, challenges such as reproducibility issues due to the multicomponent nature, off-target activation caused by premature drug release, and complex pharmacokinetics arising from assembly dissociation have hindered their clinical translation. In this study, we introduce an innovative design concept termed single molecular nanomedicine (SMNM) based on macrocyclic carrier-drug conjugates.
View Article and Find Full Text PDFAn Antitumor Dual-Responsive Host-Guest Supramolecular Polymer Based on Hypoxia-Cleavable Azocalix[4]arene.
Angew Chem Int Ed Engl
January 2023
The exploitation of specific guests which can respond to external stimuli is the main approach for the construction of stimuli-responsive supramolecular polymers (SPs) based on host-guest interactions. Most functional guests, however, fail to manifest stimuli-responses. Herein, a hypoxia-responsive dimeric azocalixarene (D-SAC4A) with outstanding hosting properties was used as the macrocyclic building block for the preparation of host stimuli-responsive SPs.
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