Publications by authors named "Anju Kombara"
Article Synopsis
- Targeted protein degradation is a new approach in drug discovery, but the natural half-life of proteins greatly influences how effective these degraders are, and this relationship hasn’t been thoroughly studied.
- Research shows that short-lived proteins can misleadingly appear to be degraded by agents that actually halt protein synthesis, like GSPT1 degraders and cytotoxic drugs.
- The findings indicate that understanding a target protein's half-life is crucial for selecting targets and designing control experiments to validate the effectiveness of new protein degrading agents.
Transcription factors (TFs) are important mediators of aberrant transcriptional programs in cancer cells. In this study, we focus on TF activity (TFa) as a biomarker for cell-line-selective anti-proliferative effects, in that high TFa predicts sensitivity to loss of function of a given gene (i.e.
View Article and Find Full Text PDFAlthough touch deposit DNA is widely used in forensic casework, its cellular and acellular contents and their biological origins are poorly understood. There is evidence that the cell-free component of DNA deposited by handling may contribute substantial genetic information; however, most research into touch DNA recovery does not separate cellular and cell-free fractions or seek to characterize their contents. This work is an important early step in developing methods to isolate the cfDNA from biological material deposited by handling.
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